Macrophages are the most abundant immune cells within the synovial joints, and also the
main innate immune effector cells triggering the initial inflammatory responses in the …

Flavonoids comprise a large group of structurally diverse polyphenolic compounds of plant
origin and are abundantly found in human diet such as fruits, vegetables, grains, tea, dairy …

Plants represent the main source of molecules for the development of new drugs, which
intensifies the interest of transnational industries in searching for substances obtained from …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …

Cardiovascular disease is a leading cause of death and reduced quality of life, proven by
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …

Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …

Noise has been found associated with annoyance, stress, sleep disturbance, and impaired
cognitive performance. Furthermore, epidemiological studies have found that environmental …

Significance: Social and demographic changes have led to an increased prevalence of
loneliness and social isolation in modern society. Recent Advances: Population-based …

Ambient air pollution is a leading cause of non-communicable disease globally. The largest
proportion of deaths and morbidity due to air pollution is now known to be due to …

The etiology of hypertension involves complex interactions among genetic, environmental,
and pathophysiologic factors that influence many regulatory systems. Hypertension is …