Twin studies to GWAS: there and back again

NP Friedman, MT Banich, MC Keller - Trends in cognitive sciences, 2021 - cell.com
The field of human behavioral genetics has come full circle. It began by using twin/family
studies to estimate the relative importance of genetic and environmental influences. As large …

Short chain fatty acid metabolism in relation to gut microbiota and genetic variability

G Ramos Meyers, H Samouda, T Bohn - Nutrients, 2022 - mdpi.com
It is widely accepted that the gut microbiota plays a significant role in modulating
inflammatory and immune responses of their host. In recent years, the host-microbiota …

[HTML][HTML] SARS-CoV-2 is associated with changes in brain structure in UK Biobank

G Douaud, S Lee, F Alfaro-Almagro, C Arthofer… - Nature, 2022 - nature.com
There is strong evidence of brain-related abnormalities in COVID-19–. However, it remains
unknown whether the impact of SARS-CoV-2 infection can be detected in milder cases, and …

Brain imaging before and after COVID-19 in UK Biobank

G Douaud, S Lee, F Alfaro-Almagro, C Arthofer… - MedRxiv, 2021 - medrxiv.org
There is strong evidence for brain-related pathologies in COVID-19, some of which could be
a consequence of viral neurotropism, or of neuroinflammation following viral infection. Most …

Mendelian randomization analyses support causal relationships between brain imaging-derived phenotypes and risk of psychiatric disorders

J Guo, K Yu, SS Dong, S Yao, Y Rong, H Wu… - Nature …, 2022 - nature.com
Observational studies have reported the correlations between brain imaging-derived
phenotypes (IDPs) and psychiatric disorders; however, whether the relationships are causal …

[HTML][HTML] Discovery of 42 genome-wide significant loci associated with dyslexia

C Doust, P Fontanillas, E Eising, SD Gordon, Z Wang… - Nature …, 2022 - nature.com
Reading and writing are crucial life skills but roughly one in ten children are affected by
dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up …

Genome-wide analyses of individual differences in quantitatively assessed reading-and language-related skills in up to 34,000 people

E Eising, N Mirza-Schreiber… - Proceedings of the …, 2022 - National Acad Sciences
The use of spoken and written language is a fundamental human capacity. Individual
differences in reading-and language-related skills are influenced by genetic variation, with …

[HTML][HTML] Phenotypic and genetic associations of quantitative magnetic susceptibility in UK Biobank brain imaging

C Wang, AB Martins-Bach, F Alfaro-Almagro… - Nature …, 2022 - nature.com
A key aim in epidemiological neuroscience is identification of markers to assess brain health
and monitor therapeutic interventions. Quantitative susceptibility mapping (QSM) is an …

[HTML][HTML] Outcome after acute ischemic stroke is linked to sex-specific lesion patterns

AK Bonkhoff, MD Schirmer, M Bretzner, S Hong… - Nature …, 2021 - nature.com
Acute ischemic stroke affects men and women differently. In particular, women are often
reported to experience higher acute stroke severity than men. We derived a low-dimensional …

X-chromosome influences on neuroanatomical variation in humans

TT Mallard, S Liu, J Seidlitz, Z Ma, D Moraczewski… - Nature …, 2021 - nature.com
The X-chromosome has long been hypothesized to have a disproportionate influence on the
brain based on its enrichment for genes that are expressed in the brain and associated with …