Artemisinins are efficacious antimalarial drugs widely employed as first-line treatment in
endemic countries under the form of combined therapies. Different molecular modes of …

The emergence and spread of multidrug resistant Plasmodium falciparum has severely
limited the therapeutic options for the treatment of malaria. With ever‐increasing failure rates …

The use of pfdhfr and pfdhps markers in determining antifolate resistance of Plasmodium
falciparum has been consolidated. Similar progress has been made with pfcrt markers for …

The malaria parasite Plasmodium vivax is known to be majorly endemic to Asian and Latin
American countries with no or very few reports of Africans infected with this parasite. Since …

ABSTRACT The involvement of Pfmdr1 (Plasmodium falciparum multidrug resistance 1)
polymorphisms in antimalarial drug resistance is still debated. Here, we evaluate the …

The spread of Plasmodium falciparum resistant parasites remains one of the major
challenges for malaria control and elimination in Sub Saharan Africa. Monitoring of …

Purpose: The introduction of artemisinin-based combination therapies (ACTs) in treating
uncomplicated malaria and sulfadoxine–pyrimethamine (SP) as intermittent preventive …

ATP-Binding Cassette (ABC) transporters are efflux pumps frequently associated with
multidrug resistance in many biological systems, including malaria. Antimalarial drug …

Antimalarial drug resistance is a major constraint for malaria control and elimination efforts.
Artemisinin-based combination therapy is now the mainstay for malaria treatment. However …

This document was prepared for the Roll Back Malaria Department of the World Health
Organization by Pascal Ringwald with the collaboration of Laura Shallcross, who was …