We study optimal radiotherapy fractionations for low-grade glioma using mathematical
models. Both space-independent and space-dependent models are studied. Two different …

This paper outlines the major components and function of the technologically integrated
oncosimulator developed primarily within the Advancing Clinico Genomic Trials on Cancer …

Background and objectives Glioblastoma multiforme (GBM) is the most common and deadly
type of primary cancers of the brain and central nervous system in adults. Despite the …

Background: Glioblastoma multiforme (GBM) is the most frequent primary brain tumor in
adults and Temozolomide (TMZ) is an effective chemotherapeutic agent for its treatment. In …

Grade II gliomas are slowly growing primary brain tumors that affect mostly young patients.
Cytotoxic therapies (radiotherapy and/or chemotherapy) are used initially only for patients …

Mathematical models have been ubiquitously employed in various applications. One of
these applications that arose in the past few decades is cerebral tumor growth modeling …

Background Intelligent and multitiered quantitative analysis of biological systems rapidly
evolves to a key technique in studying biomolecular cancer aspects. Newly emerging …

Grade II gliomas are slowly growing primary brain tumours that affect mostly young patients
and become fatal after a variable time period. Current clinical handling includes surgery as …

The tumor microenvironment (TME) presents a challenging barrier for effective nanotherapy-
mediated drug delivery to solid tumors. In particular for tumors less vascularized than the …

The" Oncosimulator" is at the same time a concept of multilevel integrative cancer and
(treatment affected) normal tissue biology, an algorithmic construct and a software tool which …