Exercise, in the form of endurance or resistance training, leads to specific molecular and
cellular adaptions not only in skeletal muscles, but also in many other organs such as the …

Skeletal muscle is endowed with a remarkable capacity for regeneration, primarily due to the
reserve pool of muscle resident satellite cells. The satellite cell is the physiologically …

The largest mammalian cells are the muscle fibers, and they have multiple nuclei to support
their large cytoplasmic volumes. During hypertrophic growth, new myonuclei are recruited …

Evidence from clinical trials and observational studies suggests that both progressive
resistance exercise training (PRT) and metformin delay a variety of age-related morbidities …

The extracellular matrix (ECM) in skeletal muscle plays an integral role in tissue
development, structural support, and force transmission. For successful adaptation to …

Dietary fish oil‐derived n‐3 PUFA supplementation can increase muscle mass, reduce
oxygen demand during physical activity, and improve physical function (muscle strength and …

Methods: Mice with total and satellite cell specific Mmp13 deletion were utilized to determine
the importance of MMP-13 for postnatal growth, regeneration after acute injury, and in …

Muscle regeneration requires the coordination of several factors to mobilize satellite cells
and macrophages, remodel the extracellular matrix surrounding muscle fibers, and repair …

Skeletal muscle extracellular matrix remodelling has been proposed as a new feature
associated with obesity and metabolic dysfunction. Exercise training improves muscle …

Methods twelve female adult sheep underwent an acute rotator cuff tear and immediate
repair on the right shoulder. The left shoulder served as a control and did not undergo a tear …