The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

Adenosine is an evolutionary ancient metabolic regulator linking energy state to physiologic
processes, including immunomodulation and cell proliferation. Tumors create an adenosine …

Red blood cell distribution width (RDW), an integral parameter of the complete blood count
(CBC), has been traditionally used for the classification of several types of anemia. However …

Myeloproliferative neoplasms are associated with increased risk for thrombotic
complications. These conditions most commonly involve somatic mutations in genes that …

The fundamental physiology of circulating red blood cells (RBCs) and platelets involving
regulation of oxygen transport and hemostasis, respectively, are well-described in the …

Background & aims Nitric oxide bioactivity (NO) from endothelial NO synthase (eNOS)
importantly contributes to the maintenance of vascular homeostasis, and reduced eNOS …

Eutrophicated waters frequently support bloom-forming cyanobacteria, many of which
produce potent cyanobacterial toxins (cyanotoxins). Cyanotoxins can cause adverse health …

High and low hematocrit (Hct) and hemoglobin (Hb) levels are associated with the risk of
cardiovascular disease. The purpose of this study was to determine the relationships of Hct …

The red blood cell (RBC)-Omics study, part of the larger NHLBI-funded Recipient
Epidemiology and Donor Evaluation Study (REDS-III), aims to understand the genetic …

We recently showed that red blood cells (RBCs) from patients with type 2 diabetes mellitus
(T2DM-RBCs) induce endothelial dysfunction through a mechanism involving arginase I and …