Synaptic dysregulation in a human iPS cell model of mental disorders
Dysregulated neurodevelopment with altered structural and functional connectivity is
believed to underlie many neuropsychiatric disorders, and 'a disease of synapses' is the …
believed to underlie many neuropsychiatric disorders, and 'a disease of synapses' is the …
PSD95: A synaptic protein implicated in schizophrenia or autism?
AA Coley, WJ Gao - Progress in Neuro-Psychopharmacology and …, 2018 - Elsevier
The molecular components of the postsynaptic density (PSD) in excitatory synapses of the
brain are currently being investigated as one of the major etiologies of neurodevelopmental …
brain are currently being investigated as one of the major etiologies of neurodevelopmental …
An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder
Genomic association studies of common or rare protein-coding variation have established
robust statistical approaches to account for multiple testing. Here we present a comparable …
robust statistical approaches to account for multiple testing. Here we present a comparable …
CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder
Schizophrenia and bipolar disorder are serious mental illnesses that affect more than 2% of
adults. While large-scale genetics studies have identified genomic regions associated with …
adults. While large-scale genetics studies have identified genomic regions associated with …
The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies
Despite the clinical significance of balanced chromosomal abnormalities (BCAs), their
characterization has largely been restricted to cytogenetic resolution. We explored the …
characterization has largely been restricted to cytogenetic resolution. We explored the …
Population structure in genetic studies: Confounding factors and mixed models
A genome-wide association study (GWAS) seeks to identify genetic variants that contribute
to the development and progression of a specific disease. Over the past 10 years, new …
to the development and progression of a specific disease. Over the past 10 years, new …
The fourth law of behavior genetics
Behavior genetics is the study of the relationship between genetic variation and
psychological traits. proposed “Three Laws of Behavior Genetics” based on empirical …
psychological traits. proposed “Three Laws of Behavior Genetics” based on empirical …
[PDF][PDF] Comparative analyses of copy-number variation in autism spectrum disorder and schizophrenia reveal etiological overlap and biological insights
I Kushima, B Aleksic, M Nakatochi, T Shimamura… - Cell reports, 2018 - cell.com
Compelling evidence in Caucasian populations suggests a role for copy-number variations
(CNVs) in autism spectrum disorder (ASD) and schizophrenia (SCZ). We analyzed 1,108 …
(CNVs) in autism spectrum disorder (ASD) and schizophrenia (SCZ). We analyzed 1,108 …
Refining the role of de novo protein-truncating variants in neurodevelopmental disorders by using population reference samples
Recent research has uncovered an important role for de novo variation in
neurodevelopmental disorders. Using aggregated data from 9,246 families with autism …
neurodevelopmental disorders. Using aggregated data from 9,246 families with autism …
[PDF][PDF] Dissecting the molecular basis of human interneuron migration in forebrain assembloids from Timothy syndrome
Defects in interneuron migration can disrupt the assembly of cortical circuits and lead to
neuropsychiatric disease. Using forebrain assembloids derived by integration of cortical and …
neuropsychiatric disease. Using forebrain assembloids derived by integration of cortical and …