Perlecan is a ubiquitous pericellular proteoglycan ideally placed to mediate cell signaling
events controlling migration, proliferation, and differentiation. Its control of growth factor …

• Introduction• ECM: composition and structure‐Collagen‐Laminin‐Fibronectin‐Elastin‐
Nidogen‐Glycosaminoglycans‐Perlecan‐Syndecans‐Receptors for ECM molecules• …

Numerous extracellular proteins and glycosaminoglycans (GAG s) undergo limited
enzymatic cleavage resulting in the release of fragments exerting biological activities, which …

Vascular development requires correct interactions among endothelial cells, pericytes and
surrounding cells. These interactions involve many cell adhesion interactions, including cell …

Normal homeostatic adjustment of elevated intraocular pressure (IOP) involves remodeling
the extracellular matrix (ECM) of the trabecular meshwork (TM). This entails sensing …

Proteoglycans located in basement membranes, the nanostructures underling epithelial and
endothelial layers, are unique in several respects. They are usually large, elongated …

The mammary gland microenvironment during postlactational involution shares similarities
with inflammation, including high matrix metalloproteinase activity, fibrillar collagen …

Snake venom metalloproteinases (SVMPs) affect the extracellular matrix (ECM) in multiple
and complex ways. Previously, the combination of various methodological platforms …

Stroke is the leading cause of long-term disability and the third leading cause of death in the
United States. While most research thus far has focused on acute stroke treatment and …

The basement membrane (BM) is a specialized layer of extracellular matrix components that
plays a central role in maintaining lung and kidney functions. Although the composition of …