ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteases
comprise the most recently discovered branch of the extracellular metalloenzymes …

To define the role of the α2β1 integrin in pathologic angiogenesis, we investigated tumor-
associated growth and angiogenesis in wild-type and α2-null mice. Our findings reveal that …

The formation of a 'tumor-associated vasculature', a process referred to as tumor
angiogenesis, is a stromal reaction essential for tumor progression. Inhibition of tumor …

Proteoglycans and selected extracellular matrix constituents are emerging as intrinsic and
critical regulators of evolutionarily conversed, intracellular catabolic pathways. Often, these …

The extracellular matrix fragment perlecan domain V is neuroprotective and functionally
restorative following experimental stroke. As neurogenesis is an important component of …

During the last 15 years, following its identification and first detailed molecular
characterization, the dystroglycan (DG) complex has taken centre stage in biology and …

The α2β1 integrin receptor plays a key role in angiogenesis. Here we investigated the
effects of small molecule inhibitors (SMIs) designed to disrupt integrin α2 I or β1 I-like …

Endogenous inhibitors of angiogenesis are proved to be a major factor preventing the
emergence of clinically manifested stages of human cancer. The protein endostatin, a 20-kD …

Cardiac function is mediated by interactions between the cellular constituents of the heart,
as well as the extracellular matrix. The major cell types of the heart include cardiac …

Corneal angiogenesis is associated with a variety of corneal diseases, and is sometimes
vision threatening. In recent years, with the discovery of major pro-and anti-angiogenic …