[PDF][PDF] Screening human embryos for polygenic traits has limited utility
The increasing proportion of variance in human complex traits explained by polygenic
scores, along with progress in preimplantation genetic diagnosis, suggests the possibility of …
scores, along with progress in preimplantation genetic diagnosis, suggests the possibility of …
A microRNA signature that correlates with cognition and is a target against cognitive decline
While some individuals age without pathological memory impairments, others develop age‐
associated cognitive diseases. Since changes in cognitive function develop slowly over time …
associated cognitive diseases. Since changes in cognitive function develop slowly over time …
[PDF][PDF] Pleiotropic meta-analysis of cognition, education, and schizophrenia differentiates roles of early neurodevelopmental and adult synaptic pathways
Susceptibility to schizophrenia is inversely correlated with general cognitive ability at both
the phenotypic and the genetic level. Paradoxically, a modest but consistent positive genetic …
the phenotypic and the genetic level. Paradoxically, a modest but consistent positive genetic …
Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders
X Yao, JT Glessner, J Li, X Qi, X Hou, C Zhu… - Translational …, 2021 - nature.com
Neuropsychiatric disorders, such as autism spectrum disorder (ASD), attention deficit
hyperactivity disorder (ADHD), schizophrenia (SCZ), bipolar disorder (BIP), and major …
hyperactivity disorder (ADHD), schizophrenia (SCZ), bipolar disorder (BIP), and major …
Genome-wide association studies of schizophrenia and bipolar disorder in a diverse cohort of US veterans
Background Schizophrenia (SCZ) and bipolar disorder (BIP) are debilitating
neuropsychiatric disorders, collectively affecting 2% of the world's population. Recognizing …
neuropsychiatric disorders, collectively affecting 2% of the world's population. Recognizing …
Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits
Structural variations of the human brain are heritable and highly polygenic traits, with
hundreds of associated genes identified in recent genome-wide association studies …
hundreds of associated genes identified in recent genome-wide association studies …
Effect of sleep and mood on academic performance—at interface of physiology, psychology, and education
KJ Mehta - Humanities and Social Sciences Communications, 2022 - nature.com
Academic achievement and cognitive functions are influenced by sleep and mood/emotion.
In addition, several other factors affect learning. A coherent overview of the resultant …
In addition, several other factors affect learning. A coherent overview of the resultant …
Cognitive ability and education: How behavioural genetic research has advanced our knowledge and understanding of their association
Cognitive ability and educational success predict positive outcomes across the lifespan,
from higher earnings to better health and longevity. The shared positive outcomes …
from higher earnings to better health and longevity. The shared positive outcomes …
[HTML][HTML] Genome-wide association study of Alzheimer's disease brain imaging biomarkers and neuropsychological phenotypes in the European medical information …
J Homann, T Osburg, O Ohlei, V Dobricic… - Frontiers in aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is the most frequent neurodegenerative disease with an
increasing prevalence in industrialized, ageing populations. AD susceptibility has an …
increasing prevalence in industrialized, ageing populations. AD susceptibility has an …
Convergence and divergence of rare genetic disorders on brain phenotypes: a review
Importance Rare genetic disorders modulating gene expression—as exemplified by gene
dosage disorders (GDDs)—represent a collectively common set of high-risk factors for …
dosage disorders (GDDs)—represent a collectively common set of high-risk factors for …