Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

Formation of the human heart involves complex biological signals, interactions, specification
of myocardial progenitor cells, and heart tube looping. To facilitate survival in the hypoxemic …

Most methods for single-cell transcriptome sequencing amplify the termini of polyadenylated
transcripts, capturing only a small fraction of the total cellular transcriptome. This precludes …

Congenital heart defects constitute the most common human birth defect, however
understanding of how these disorders originate is limited by our ability to model the human …

Abstract The Hippo–YAP (Yes-associated protein) pathway is an evolutionarily and
functionally conserved regulator of organ size and growth with crucial roles in cell …

Stem-cell differentiation to desired lineages requires navigating alternating developmental
paths that often lead to unwanted cell types. Hence, comprehensive developmental …

Our understanding of the spatiotemporal regulation of cardiogenesis is hindered by the
difficulties in modeling this complex organ currently by in vitro models. Here we develop a …

Multipotent adult resident cardiac stem cells (CSCs) were first identified by the expression of
c-kit, the stem cell factor receptor. However, in the adult myocardium c-kit alone cannot …

Conversion of fibroblasts to functional cardiomyocytes represents a potential approach for
restoring cardiac function after myocardial injury, but the technique thus far has been slow …

In the past few decades, cardiac regeneration has been the central target for restoring the
injured heart. In mammals, cardiomyocytes are terminally differentiated and rarely divide …