Viral burden rebound in hospitalised patients with COVID-19 receiving oral antivirals in Hong Kong: a population-wide retrospective cohort study
Background Viral rebound after nirmatrelvir–ritonavir treatment has implications for the
clinical management and isolation of patients with COVID-19. We evaluated an unselected …
clinical management and isolation of patients with COVID-19. We evaluated an unselected …
A simple model of COVID-19 explains disease severity and the effect of treatments
Considerable effort has been made to better understand why some people suffer from
severe COVID-19 while others remain asymptomatic. This has led to important clinical …
severe COVID-19 while others remain asymptomatic. This has led to important clinical …
Within-host evolution of SARS-CoV-2: how often are de novo mutations transmitted from symptomatic infections?
CS Korosec, LM Wahl, JM Heffernan - Virus Evolution, 2024 - academic.oup.com
Despite a relatively low mutation rate, the large number of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infections has allowed for substantial genetic …
syndrome coronavirus 2 (SARS-CoV-2) infections has allowed for substantial genetic …
Modeling explains prolonged SARS-CoV-2 nasal shedding relative to lung shedding in remdesivir-treated rhesus macaques
In clinical trials, remdesivir decreased recovery time in hospitalized patients with SARS-CoV-
2 and prevented hospitalization when given early during infection, despite not reducing …
2 and prevented hospitalization when given early during infection, despite not reducing …
[HTML][HTML] Viral load rebound in placebo and nirmatrelvir-ritonavir treated COVID-19 patients is not associated with recurrence of severe disease or mutations
H Soares, ML Baniecki, R Cardin, H Leister-Tebbe… - 2022 - europepmc.org
Nirmatrelvir-ritonavir was developed for the treatment of COVID-19 and has shown efficacy
in a Phase 2/3 study of high risk patients (EPIC-HR1). Monitoring for the emergence of viral …
in a Phase 2/3 study of high risk patients (EPIC-HR1). Monitoring for the emergence of viral …
A quantitative systems pharmacology model of the pathophysiology and treatment of COVID-19 predicts optimal timing of pharmacological interventions
A quantitative systems pharmacology (QSP) model of the pathogenesis and treatment of
SARS-CoV-2 infection can streamline and accelerate the development of novel medicines to …
SARS-CoV-2 infection can streamline and accelerate the development of novel medicines to …
[HTML][HTML] Two-strain mathematical virus model with delay for Covid-19 with immune response
IO Abdallah, PMT Djomegni, MSD Haggar… - Alexandria Engineering …, 2023 - Elsevier
In this manuscript, we analyze a new virus model of SARS-CoV-2 infection with immune
response. The initial model was proposed by Mochan et al.[23] to describe an experiment …
response. The initial model was proposed by Mochan et al.[23] to describe an experiment …
Development of a SARS‐CoV‐2 viral dynamic model for patients with COVID‐19 based on the amount of viral RNA and viral titer
D Yamaguchi, R Shimizu… - CPT: Pharmacometrics & …, 2024 - Wiley Online Library
The target‐cell limited model, which is one of the mathematical modeling approaches
providing a quantitative understanding of viral dynamics, has been applied to describe viral …
providing a quantitative understanding of viral dynamics, has been applied to describe viral …
Severe acute respiratory syndrome-coronavirus-2 (SARS-COV-2) infection of pneumocytes with vaccination and drug therapy: Mathematical analysis and optimal …
R Viriyapong, P Inkhao - International Journal of Biomathematics, 2024 - World Scientific
We propose a mathematical model studying a within-host infection dynamics of SARS-CoV-
2 in pneumocytes. This model incorporates immune response, vaccination and antiviral …
2 in pneumocytes. This model incorporates immune response, vaccination and antiviral …
Population Approach Group Europe Population Approach Group Europe
R Kubota - page-meeting.org
Welcome to the Population Approach Group in Europe Population Approach Group Europe
Population Approach Group Europe My profile Search abstracts Sheiner Student Session …
Population Approach Group Europe My profile Search abstracts Sheiner Student Session …