[HTML][HTML] The drug repurposing for COVID-19 clinical trials provide very effective therapeutic combinations: lessons learned from major clinical studies

C Chakraborty, AR Sharma, M Bhattacharya… - Frontiers in …, 2021 - frontiersin.org
SARS-CoV-2 has spread across the globe in no time. In the beginning, people suffered due
to the absence of efficacious drugs required to treat severely ill patients. Nevertheless, still …

The interplay between inflammatory pathways and COVID-19: A critical review on pathogenesis and therapeutic options

S Choudhary, K Sharma, O Silakari - Microbial pathogenesis, 2021 - Elsevier
Abstract COVID-19, caused by SARS-CoV-2, emerged as the deadliest outbreak that has
now become a serious health issue to mankind. Activation of inflammatory signaling …

The landscape of candidemia during the coronavirus disease 2019 (COVID-19) pandemic

EE Seagle, BR Jackson, SR Lockhart… - Clinical Infectious …, 2022 - academic.oup.com
Background The COVID-19 pandemic has resulted in unprecedented healthcare
challenges, and COVID-19 has been linked to secondary infections. Candidemia, a fungal …

Rational approach toward COVID-19 main protease inhibitors via molecular docking, molecular dynamics simulation and free energy calculation

S Keretsu, SP Bhujbal, SJ Cho - Scientific reports, 2020 - nature.com
In the rapidly evolving coronavirus disease (COVID-19) pandemic, repurposing existing
drugs and evaluating commercially available inhibitors against druggable targets of the virus …

SARS-CoV-2 causes a different cytokine response compared to other cytokine storm-causing respiratory viruses in severely ill patients

M Olbei, I Hautefort, D Modos, A Treveil… - Frontiers in …, 2021 - frontiersin.org
Hyper-induction of pro-inflammatory cytokines, also known as a cytokine storm or cytokine
release syndrome (CRS), is one of the key aspects of the currently ongoing SARS-CoV-2 …

Abnormal immunity of non-survivors with COVID-19: predictors for mortality

Y Zhao, HX Nie, K Hu, XJ Wu, YT Zhang… - Infectious diseases of …, 2020 - Springer
Background The number of coronavirus disease 2019 (COVID-19) cases has rapidly
increased all over the world. Specific information about immunity in non-survivors with …

[HTML][HTML] Repurposing drugs, ongoing vaccine, and new therapeutic development initiatives against COVID-19

RP Saha, AR Sharma, MK Singh, S Samanta… - Frontiers in …, 2020 - frontiersin.org
As the COVID-19 is still growing throughout the globe, a thorough investigation into the
specific immunopathology of SARS-CoV-2, its interaction with the host immune system and …

Microstructure, pathophysiology, and potential therapeutics of COVID‐19: a comprehensive review

SP Singh, M Pritam, B Pandey… - Journal of medical …, 2021 - Wiley Online Library
There have been over seven million cases and almost 413 372 deaths globally due to the
novel coronavirus (2019‐nCoV) associated disease COVID‐19, as of 11 June 2020 …

Medicinal plants in COVID-19: potential and limitations

XY Lim, BP Teh, TYC Tan - Frontiers in pharmacology, 2021 - frontiersin.org
Currently, the search to identify treatments and vaccines for novel coronavirus disease
(COVID-19) are ongoing. Desperation within the community, especially among the middle …

[PDF][PDF] Coronavirus-19 (SARS-CoV-2) induces acute severe lung inflammation via IL-1 causing cytokine storm in COVID-19: a promising inhibitory strategy

P Conti, A Caraffa, CE Gallenga, R Ross… - J Biol Regul Homeost …, 2020 - researchgate.net
SARS-Cov-2 infection causes local and systemic inflammation mediated by pro-
inflammatory cytokines and COX-2 eicosanoid products with metabolic dysfunction and …