ABSTRACT rRNAs are extensively modified during their transcription and subsequent
maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed …

Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

Chemical modifications of human ribosomal RNA (rRNA) are introduced during biogenesis
and have been implicated in the dysregulation of protein synthesis, as is found in cancer …

The proteome of cells is synthesized by ribosomes, complex ribonucleoproteins that in
eukaryotes contain 79–80 proteins and four ribosomal RNAs (rRNAs) more than 5,400 …

Structures of the bacterial ribosome have provided a framework for understanding universal
mechanisms of protein synthesis. However, the eukaryotic ribosome is much larger than it is …

Ribosomes play a pivotal role in the molecular life of every cell. Moreover, synthesis of
ribosomes is one of the most energetically demanding of all cellular processes. In eukaryotic …

The assembly of ribosomes from a discrete set of components is a key aspect of the highly
coordinated process of ribosome biogenesis. In this review, we present a brief history of the …

Ribose methylations are the most abundant chemical modifications of ribosomal RNA and
are critical for ribosome assembly and fidelity of translation. Many aspects of ribose …

Several proto-oncogenes and tumor suppressors regulate the production of ribosomes.
Ribosome biogenesis is a major consumer of cellular energy, and defects result in p53 …

The ribosome, central to protein synthesis in all cells, is a complex multicomponent
assembly with rRNA at its functional core. During the process of ribosome biogenesis …