Longevity is a hallmark of successful ageing and a complex trait with a significant genetic
component. In this study, 43 single nucleotide polymorphisms (SNPs) were chosen from the …

Exceptional longevity is associated with substantial heritability. The ɛ4 allele in
apolipoprotein E and the linked G allele in rs2075650 of TOMM40 have been associated …

The age-specific prevalence rates of dementia vary widely. Studies focusing on specific age
groups are needed to provide reliable estimates for healthcare providers and policy makers …

Polygenic risk scores (PRS) are a method increasingly used to capture the combined effect
of genome‐wide significant variants and those which individually do not show genome‐wide …

Usually the genetics of human longevity is restricted to the nuclear genome (nDNA).
However it is well known that the nDNA interacts with a physically and functionally …

Frailty, a prevalent clinical syndrome in aging adults, is characterized by poor health
outcomes, represented via a standardized frailty-phenotype (FP), and Frailty Index (FI) …

Purpose Human longevity results from a number of factors, including genetic background,
favorable environmental, social factors and chance. In this study, we aimed to elucidate the …

Resting-state functional connectivity is suggested to be cross-sectionally associated with
both vascular burden and Alzheimer's disease (AD) pathology. However, evidence is …

Multi-omics approaches including proteomics analyses are becoming an integral
component of precision medicine. As clinical proteomics studies gain momentum and their …

Gene variants found to associate with human longevity in one population rarely replicate in
other populations. The lack of consistent findings may partly be explained by genetic …