Late-Stage C–H Functionalization of Azines

CM Josephitis, HMH Nguyen, A McNally - Chemical reviews, 2023 - ACS Publications
Azines, such as pyridines, quinolines, pyrimidines, and pyridazines, are widespread
components of pharmaceuticals. Their occurrence derives from a suite of physiochemical …

[HTML][HTML] Pyridine: the scaffolds with significant clinical diversity

S De, AK SK, SK Shah, S Kazi, N Sarkar, S Banerjee… - Rsc Advances, 2022 - pubs.rsc.org
The nitrogen-bearing heterocycle pyridine in its several analogous forms occupies an
important position as a precious source of clinically useful agents in the field of medicinal …

Enantio- and Regioselective Ni-Catalyzed para-C–H Alkylation of Pyridines with Styrenes via Intermolecular Hydroarylation

JB Ma, X Zhao, D Zhang, SL Shi - Journal of the American …, 2022 - ACS Publications
Direct asymmetric functionalization of the pyridyl C–H bond represents a longstanding
challenge in organic chemistry. We herein describe the first enantioselective para-C–H …

Diboron (4)‐Catalyzed Remote [3+ 2] Cycloaddition of Cyclopropanes via Dearomative/Rearomative Radical Transmission through Pyridine

M Xu, Z Wang, Z Sun, Y Ouyang, Z Ding… - Angewandte …, 2022 - Wiley Online Library
Ring structures such as pyridine, cyclopentane or their combinations are important motifs in
bioactive molecules. In contrast to previous cycloaddition reactions that necessitated a …

[HTML][HTML] Pyridine compounds with antimicrobial and antiviral activities

M Marinescu, CV Popa - International journal of molecular sciences, 2022 - mdpi.com
In the context of the new life-threatening COVID-19 pandemic caused by the SARS-CoV-2
virus, finding new antiviral and antimicrobial compounds is a priority in current research …

Recent advances in pyridine scaffold: Focus on chemistry, synthesis, and antibacterial activities

MB Islam, MI Islam, N Nath, TB Emran… - BioMed research …, 2023 - Wiley Online Library
Multidrug‐resistant (MDR) pathogens have created a fatal problem for human health and
antimicrobial treatment. Among the currently available antibiotics, many are inactive against …

Emerging impact of triazoles as anti-tubercular agent

A Sharma, AK Agrahari, S Rajkhowa… - European Journal of …, 2022 - Elsevier
Tuberculosis, a disease of poverty is a communicable infection with a reasonably high
mortality rate worldwide. 10 Million new cases of TB were reported with approx 1.4 million …

Late-Stage Saturation of Drug Molecules

DH Liu, PM Pflüger, A Outlaw… - Journal of the …, 2024 - ACS Publications
The available methods of chemical synthesis have arguably contributed to the prevalence of
aromatic rings, such as benzene, toluene, xylene, or pyridine, in modern pharmaceuticals …

Synthesis, Characterization, Bioactivity Screening and Computational Studies of Diphenyl− malonohydrazides and Pyridines Derivatives

MM Barqi, IM Abdellah, MR Eletmany, NM Ali… - …, 2023 - Wiley Online Library
A series of new hydrazide (3 a–j) and pyridine (11 a–j) derivatives were synthesized using a
convergent synthetic methodology by condensation of malono‐di (2‐phenylhydrazide) with …

Multitargeted platinum (IV) anticancer complexes bearing pyridinyl ligands as axial leaving groups

Q Zhou, S Chen, Z Xu, G Liu, S Zhang… - Angewandte …, 2023 - Wiley Online Library
Although multitargeted PtIV anticancer prodrugs have shown significant activities in
reducing drug resistance, the types of bioactive ligands and drugs that can be conjugated to …