Integrated multi-omics approaches to improve classification of chronic kidney disease
S Eddy, LH Mariani, M Kretzler - Nature Reviews Nephrology, 2020 - nature.com
Chronic kidney diseases (CKDs) are currently classified according to their clinical features,
associated comorbidities and pattern of injury on biopsy. Even within a given classification …
associated comorbidities and pattern of injury on biopsy. Even within a given classification …
Transgenic fluorescent zebrafish lines that have revolutionized biomedical research
CP Choe, SY Choi, Y Kee, MJ Kim, SH Kim… - Laboratory Animal …, 2021 - Springer
Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …
vertebrate model organism in more than 40,000 biomedical research studies. Especially …
Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease
More than 800 million people suffer from kidney disease, yet the mechanism of kidney
dysfunction is poorly understood. In the present study, we define the genetic association with …
dysfunction is poorly understood. In the present study, we define the genetic association with …
Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis
We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ancestry meta-analysis
of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE …
of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE …
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure
to identify genes, tissues, phenomes and medication contexts of blood pressure …
to identify genes, tissues, phenomes and medication contexts of blood pressure …
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels
Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via
poorly understood mechanisms. We performed a trans-ancestry genome-wide association …
poorly understood mechanisms. We performed a trans-ancestry genome-wide association …
Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments
The functional interpretation of genome-wide association studies (GWAS) is challenging due
to the cell-type-dependent influences of genetic variants. Here, we generated …
to the cell-type-dependent influences of genetic variants. Here, we generated …
Renal compartment–specific genetic variation analyses identify new pathways in chronic kidney disease
Chronic kidney disease (CKD), a condition in which the kidneys are unable to clear waste
products, affects 700 million people globally. Genome-wide association studies (GWASs) …
products, affects 700 million people globally. Genome-wide association studies (GWASs) …
Transcriptome-wide association analysis identifies DACH1 as a kidney disease risk gene that contributes to fibrosis
Genome-wide association studies (GWAS) for kidney function identified hundreds of risk
regions; however, the causal variants, target genes, cell types, and disease mechanisms …
regions; however, the causal variants, target genes, cell types, and disease mechanisms …
A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
Genome-wide association studies (GWAS) have identified loci for kidney disease, but the
causal variants, genes, and pathways remain unknown. Here we identify two kidney disease …
causal variants, genes, and pathways remain unknown. Here we identify two kidney disease …