Biological activity of ionic liquids and their application in pharmaceutics and medicine

KS Egorova, EG Gordeev, VP Ananikov - Chemical reviews, 2017 - ACS Publications
Ionic liquids are remarkable chemical compounds, which find applications in many areas of
modern science. Because of their highly tunable nature and exceptional properties, ionic …

[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease

K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Regulation of pain and itch by TRP channels

C Moore, R Gupta, SE Jordt, Y Chen, WB Liedtke - Neuroscience bulletin, 2018 - Springer
Nociception is an important physiological process that detects harmful signals and results in
pain perception. In this review, we discuss important experimental evidence involving some …

Pharmacological effects of cannabidiol by transient receptor potential channels

L Etemad, G Karimi, MS Alavi, A Roohbakhsh - Life Sciences, 2022 - Elsevier
Cannabidiol (CBD), as a major phytocannabinoid of Cannabis sativa, has emerged as a
promising natural compound in the treatment of diseases. Its diverse pharmacological …

Involvement of Opioid System and TRPM8/TRPA1 Channels in the Antinociceptive Effect of Spirulina platensis

MA Freitas, A Vasconcelos, ECD Gonçalves… - Biomolecules, 2021 - mdpi.com
Spirulina platensis is a “super-food” and has attracted researchers' attention due to its anti-
inflammatory, antioxidant, and analgesic properties. Herein, we investigated the …

Sensory TRP channels in three dimensions

MM Diver, JV Lin King, D Julius… - Annual review of …, 2022 - annualreviews.org
Transient receptor potential (TRP) ion channels are sophisticated signaling machines that
detect a wide variety of environmental and physiological signals. Every cell in the body …

Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca2+ efflux and disrupted by PSEN1 loss of function

PPY Lie, L Yoo, CN Goulbourne, MJ Berg… - Science …, 2022 - science.org
Dysfunction and mistrafficking of organelles in autophagy-and endosomal-lysosomal
pathways are implicated in neurodegenerative diseases. Here, we reveal selective …

Crystal structure of the epithelial calcium channel TRPV6

K Saotome, AK Singh, MV Yelshanskaya… - Nature, 2016 - nature.com
Precise regulation of calcium homeostasis is essential for many physiological functions. The
Ca2+-selective transient receptor potential (TRP) channels TRPV5 and TRPV6 play vital …

Nanoparticles-mediated ion channels manipulation: From their membrane interactions to bioapplications

Q Huang, W Zhu, X Gao, X Liu, Z Zhang… - Advanced Drug Delivery …, 2023 - Elsevier
Ion channels are transmembrane proteins ubiquitously expressed in all cells that control
various ions (eg Na+, K+, Ca 2+ and Cl-etc) crossing cellular plasma membrane, which play …

TRP channels role in pain associated with neurodegenerative diseases

M Duitama, V Vargas-López, Z Casas… - Frontiers in …, 2020 - frontiersin.org
Transient receptor potential (TRP) are cation channels expressed in both non-excitable and
excitable cells from diverse tissues, including heart, lung, and brain. The TRP channel family …