[HTML][HTML] Cardiovascular risk and testosterone–from subclinical atherosclerosis to lipoprotein function to heart failure
B Gencer, M Bonomi, MP Adorni, CR Sirtori… - Reviews in Endocrine …, 2021 - Springer
The cardiovascular (CV) benefit and safety of treating low testosterone conditions is a matter
of debate. Although testosterone deficiency has been linked to a rise in major adverse CV …
of debate. Although testosterone deficiency has been linked to a rise in major adverse CV …
Genetic, molecular, and cellular determinants of sex-specific cardiovascular traits
Despite the well-known sex dimorphism in cardiovascular disease traits, the exact genetic,
molecular, and cellular underpinnings of these differences are not well understood. A …
molecular, and cellular underpinnings of these differences are not well understood. A …
GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background
Genome-wide association studies (GWAS) have been used to study the genetic basis of a
wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for …
wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for …
[PDF][PDF] Amplification is the primary mode of gene-by-sex interaction in complex human traits
Sex differences in complex traits are suspected to be in part due to widespread gene-by-sex
interactions (GxSex), but empirical evidence has been elusive. Here, we infer the mixture of …
interactions (GxSex), but empirical evidence has been elusive. Here, we infer the mixture of …
[HTML][HTML] Identifying and ranking causal biochemical biomarkers for breast cancer: a Mendelian randomisation study
Background Only a few of the 34 biochemical biomarkers measured in the UK Biobank
(UKB) have been associated with breast cancer, with many associations suffering from …
(UKB) have been associated with breast cancer, with many associations suffering from …
Genetically predicted circulating concentrations of micronutrients and risk of breast cancer: a Mendelian randomization study
The epidemiological literature reports inconsistent associations between consumption or
circulating concentrations of micronutrients and breast cancer risk. We investigated …
circulating concentrations of micronutrients and breast cancer risk. We investigated …
[HTML][HTML] l-carnitine, a friend or foe for cardiovascular disease? A Mendelian randomization study
Background l-carnitine is emerging as an item of interest for cardiovascular disease (CVD)
prevention and treatment, but controversy exists. To examine the effectiveness and safety of …
prevention and treatment, but controversy exists. To examine the effectiveness and safety of …
[HTML][HTML] Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Background Genetic variants within nearly 1000 loci are known to contribute to modulation
of blood lipid levels. However, the biological pathways underlying these associations are …
of blood lipid levels. However, the biological pathways underlying these associations are …
[HTML][HTML] Sex-specific features of the correlation between GWAS-noticeable polymorphisms and hypertension in Europeans of Russia
The aim of the study was directed at studying the sex-specific features of the correlation
between genome-wide association studies (GWAS)-noticeable polymorphisms and …
between genome-wide association studies (GWAS)-noticeable polymorphisms and …
Gene-based association study reveals a distinct female genetic signal in primary hypertension
Hypertension is a polygenic disease that affects over 1.2 billion adults aged 30–79
worldwide. It is a major risk factor for renal, cerebrovascular, and cardiovascular diseases …
worldwide. It is a major risk factor for renal, cerebrovascular, and cardiovascular diseases …