Sex-specific features of the correlation between GWAS-noticeable polymorphisms and hypertension in Europeans of Russia
The aim of the study was directed at studying the sex-specific features of the correlation
between genome-wide association studies (GWAS)-noticeable polymorphisms and …
between genome-wide association studies (GWAS)-noticeable polymorphisms and …
Cross-ancestry genome-wide association studies of sex hormone concentrations in pre-and postmenopausal women
Objective Concentrations of circulating sex hormones have been associated with a variety of
diseases in women and are strongly influenced by menopausal status. We investigated the …
diseases in women and are strongly influenced by menopausal status. We investigated the …
Familial aggregation and shared genetic loading for major psychiatric disorders and type 2 diabetes
Aims/hypothesis Psychiatric disorders, such as schizophrenia (SCZ), major depressive
disorder (MDD) and bipolar disorder (BPD), are highly comorbid with type 2 diabetes …
disorder (MDD) and bipolar disorder (BPD), are highly comorbid with type 2 diabetes …
Genome-wide association study identifies genetic regulation of oestrone concentrations and association with endometrial cancer risk in postmenopausal women
Background Oestrone, predominantly made in fat, is the main circulating oestrogen and
important for target tissue oestradiol production in women after menopause. The present …
important for target tissue oestradiol production in women after menopause. The present …
Gene-based association study reveals a distinct female genetic signal in primary hypertension
Hypertension is a polygenic disease that affects over 1.2 billion adults aged 30–79
worldwide. It is a major risk factor for renal, cerebrovascular, and cardiovascular diseases …
worldwide. It is a major risk factor for renal, cerebrovascular, and cardiovascular diseases …
Interrogating Causal Effects of Body Composition and Puberty‐Related Risk Factors on Adolescent Idiopathic Scoliosis: A Two‐Sample Mendelian Randomization …
Adolescent idiopathic scoliosis (AIS) is the most common form of pediatric musculoskeletal
disorder. Observational studies have pointed to several risk factors for AIS, but almost no …
disorder. Observational studies have pointed to several risk factors for AIS, but almost no …
A systematic evaluation of the performance and properties of the UK Biobank Polygenic Risk Score (PRS) Release
DJ Thompson, D Wells, S Selzam, I Peneva, R Moore… - PloS one, 2024 - journals.plos.org
We assess the UK Biobank (UKB) Polygenic Risk Score (PRS) Release, a set of PRSs for 28
diseases and 25 quantitative traits that has been made available on the individuals in UKB …
diseases and 25 quantitative traits that has been made available on the individuals in UKB …
Beyond apples and pears: sex-specific genetics of body fat percentage
Introduction Biological sex influences both overall adiposity and fat distribution. Further,
testosterone and sex hormone binding globulin (SHBG) influence adiposity and metabolic …
testosterone and sex hormone binding globulin (SHBG) influence adiposity and metabolic …
Fathers and sons, mothers and daughters: Sex-specific genetic architecture for fetal testosterone in a wild mammal
Testosterone plays a critical role in mediating fitness-related traits in many species. Although
it is highly responsive to environmental and social conditions, evidence from several species …
it is highly responsive to environmental and social conditions, evidence from several species …
A scalable and robust variance components method reveals insights into the architecture of gene-environment interactions underlying complex traits
Understanding the contribution of gene-environment interactions (GxE) to complex trait
variation can provide insights into disease mechanisms, explain sources of heritability, and …
variation can provide insights into disease mechanisms, explain sources of heritability, and …