Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …

The functional state of T cells is a key determinant for effective antitumor immunity and
immunotherapy. Cellular metabolism, including lipid metabolism, controls T cell …

In spite of high rates of complete remission following chimeric antigen receptor (CAR) T cell
therapy, the efficacy of this approach is limited by generation of dysfunctional CAR T cells in …

Cancer immunotherapy comes of age and looks for maturity | Nature Communications Skip
to main content Thank you for visiting nature.com. You are using a browser version with …

The senescence‐associated secretory phenotype (SASP), where senescent cells produce a
variety of secreted proteins including inflammatory cytokines, chemokines, matrix …

Background Immune exhaustion and senescence are dominant dysfunctional states of
effector T cells and major hurdles for the success of cancer immunotherapy. In the current …

The failure of T cells to eradicate tumour cells in the tumour microenvironment is mainly due
to the dysfunction of T cells. Senescent T cells, with defects in proliferation and effector …

Cellular senescence is a stress response associated with aging and disease, including
cancer. Senescent cells undergo a stable cell cycle arrest, undergo a change in morphology …

Background Current immunotherapies still have limited successful rates among cancers. It is
now recognized that T cell functional state in the tumor microenvironment (TME) is a key …