Vibration therapy may be useful as a primary treatment as well as an adjunct to both
physical and pharmacological treatments, but future studies must pay close attention to …

The present study observed significant effects of whole-body vibration (WBV) on bone
mineral density (BMD) in postmenopausal women, with high-quality evidence for high …

Recognized for nearly 100 years, bone marrow adipocytes (BMAs) form bone marrow
niches that contain hematopoietic and bone cells, the roles of which have long been …

Mechanical disuse will bias bone marrow stromal cells towards adipogenesis, ultimately
compromising the regenerative capacity of the stem cell pool and impeding the rapid and full …

Adult stem cells can differentiate into multiple lineages depending on their exposure to
differing biochemical and biomechanical inductive factors. Lack of mechanical signals due …

While bone tissue is a hierarchically organized material, mathematical formulations of bone
remodeling are often defined on the level of a millimeter-sized representative volume …

Aging induces alterations in bone structure and strength through a multitude of processes,
exacerbating common aging-related diseases like osteoporosis and osteoarthritis. Cellular …

Notch receptors play a role in skeletal development and homeostasis, and Notch activation
in undifferentiated and mature osteoblasts causes osteopenia. In contrast, Notch activation …

Fracture healing is impaired in aged and osteoporotic individuals. Because adequate
mechanical stimuli are able to increase bone formation, one therapeutical approach to treat …

Mechanical stimulation is an essential factor affecting the metabolism of bone cells and their
precursors. We hypothesized that vibration loading would stimulate differentiation of human …