Background: Chemoresistance to 5-fluorouracil (5-FU) is a major barrier to influence the
treatment efficiency of colorectal cancer (CRC) patients, while the precise molecular …

Epigenetic regulation involves a range of sophisticated processes which contribute to
heritable alterations in gene expression without altering DNA sequence. Regulatory events …

RNA can be modified by over 170 types of distinct chemical modifications, and the most
abundant internal modification of mRNA in eukaryotes is N6-methyladenosine (m 6 A). The …

Abstract N6-methyladenosine (m6A) methylation is the most universal internal modification
in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and …

N6-methyladenosine (m 6 A) is the most common RNA modification and has an important
role in normal development and tumorigenesis. The abnormal expression of m 6 A …

To explore the effect of insulin‐like growth factor 2 mRNA‐binding protein 2 (IGF2BP2) on
colorectal cancer (CRC) by recognizing the m6A modification of YAP mRNA thus activating …

Long noncoding RNAs (lncRNA) are involved in tumorigenesis and drug resistance.
However, the roles and underlying mechanisms of lncRNAs in colorectal cancer are still …

The RNA-binding protein IGF2BP2/IMP2/VICKZ2/p62 is overexpressed in several tumor
entities, promotes tumorigenesis and tumor progression, and has been suggested to worsen …

The human insulin-like growth factor 2 (IGF2) mRNA binding protein family (IMPs/IGF2BPs)
is involved in a spectrum of biological processes, including development, tumorigenesis …

Background As reported, preclinical animal models differ greatly from the human body. The
evaluation model may be the colossal obstacle for scientific research and anticancer drug …