Dietary habits have drastically changed over the last decades in Western societies. The
Western diet, rich in saturated fatty acids (SFA), trans fatty acids (TFA), omega-6 …

Adipose tissue is a dynamic organ in the endocrine system that can connect organs by
secreting molecules and bioactive. Hence, adipose tissue really plays a pivotal role in …

Obesity is associated with several diseases, including mental health. Adipose tissue is
distributed around the internal organs, acting in the regulation of metabolism by storing and …

Abstract d-β-hydroxybutyrate (d-3HB), a monomer of microbial polyhydroxybutyrate (PHB), is
also a natural ketone body produced during carbohydrate deprivation to provide energy to …

Microglia are brain resident macrophages, which actively survey the surrounding
microenvironment and promote tissue homeostasis under physiological conditions. During …

Alarming statistics show that the number of people affected by excessive weight has
surpassed 2 billion, representing approximately 30% of the world's population. The aim of …

A decrease in the activity of the insulin signaling system of the brain, due to both central
insulin resistance and insulin deficiency, leads to neurodegeneration and impaired …

Adult hippocampal neurogenesis (AHN), the lifelong process of formation of new neurons in
the mammalian brain, plays an important role in learning and memory. Exercise is an …

In this study, we investigated the protective effects of SM on skeletal muscle and brain
damage by regulation of BDNF/PGC1α/irisin pathway via brain function related myokines in …

There has been a progressive increase in the prevalence of obesity and its comorbidities
such as type 2 diabetes and cardiovascular diseases worldwide. Recent studies have …