Abstract Purpose of Review Bone regeneration plays an important role in contemporary
clinical treatment. Bone tissue engineering should result in successful bone regeneration to …

Osteocytes respond to mechanical forces controlling osteoblast and osteoclast function.
Mechanical stimulation decreases osteocyte apoptosis and promotes bone formation …

The principal purpose of tissue engineering is to stimulate the injured or unhealthy tissues to
revive their primary function through the simultaneous use of chemical agents, cells, and …

Introduction Methotrexate (MTX)-related osteopathy is rare, defined by the triad of pain,
osteoporosis, and “atypical fractures” when it was first described in the 1970s in children …

Purpose Bone remodeling is affected by mechanical stimulation. Osteocytes are the primary
mechanical load-sensing cells in the bone, and can regulate osteoblast and osteoclast …

Bone fracture repair is a multiphased regenerative process requiring paracrine intervention
throughout the healing process. Mesenchymal stem cells (MSCs) play a crucial role in cell …

Joint replacement is a common surgery and is predominantly utilized for treatment of
osteoarthritis in the aging population. The longevity of many of these implants depends on …

During the past several years, pre-clinical experiments have established that microRNAs
(miRNAs), small non-coding RNAs, serve as key regulatory molecules of fracture healing …

As an endogenous signaling molecule, metal ions not only play an important role in the
physiological development of the maxillofacial bone, but also can improve the repair of …

The prevalence of osteoporotic fracture is high due to global aging problem. Delayed and
impaired healing in osteoporotic fractures increase the socioeconomic burden significantly …