Molecular targeted therapies are revolutionized therapeutics which interfere with specific
molecules to block cancer growth, progression, and metastasis. Many molecular targeted …

Tumours display considerable variation in the patterning and properties of angiogenic blood
vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming …

A low vitamin D status is associated with an increased risk of various cancers, such as of
colon, breast, prostate and hematological cells. The biologically most active vitamin D …

Pathological angiogenesis is a hallmark of cancer and a therapeutic target. Vascular
endothelial growth factor A (VEGFA) and angiopoietin-2 (ANGPT2; also known as ANG2) …

Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

After cardiovascular disease, cancer is the leading cause of death worldwide with
devastating health and economic consequences, particularly in developing countries. Inter …

Cancer is a multifactorial disease and is one of the leading causes of death worldwide. The
contributing factors include specific genetic background, chronic exposure to various …

Tumor-associated macrophages (TAMs) promote key processes in tumor progression, like
angiogenesis, immunosuppression, invasion, and metastasis. Increasing studies have also …

Angiogenesis is a critical step in the progression of almost all human malignancies and
some other life-threatening diseases. Anti-angiogenic therapy is a novel and effective …

Over the past decade, whole genome sequencing and other'omics' technologies have
defined pathogenic driver mutations to which tumor cells are addicted. Such addictions …