15 years of GWAS discovery: Realizing the promise
It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …
Here, we review how this experimental design has realized its promise by facilitating an …
Addressing the ethical and societal challenges posed by genome-wide association studies of behavioral and brain-related traits
MC de Hemptinne, D Posthuma - Nature neuroscience, 2023 - nature.com
Addressing the ethical and societal challenges posed by genome-wide association studies of
behavioral and brain-related traits | Nature Neuroscience Skip to main content Thank you for …
behavioral and brain-related traits | Nature Neuroscience Skip to main content Thank you for …
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses
Depression is a common psychiatric disorder and a leading cause of disability worldwide.
Here we conducted a genome-wide association study meta-analysis of six datasets …
Here we conducted a genome-wide association study meta-analysis of six datasets …
Illuminating the 'healthy obese'phenotype
M Rask-Andersen, Å Johansson - Nature Metabolism, 2023 - nature.com
Some individuals with obesity have a healthy metabolic profile and are not at increased risk
for diabetes or cardiovascular disease. The mechanisms behind this phenomenon are …
for diabetes or cardiovascular disease. The mechanisms behind this phenomenon are …
Precision medicine in complex diseases—Molecular subgrouping for improved prediction and treatment stratification
Complex diseases are caused by a combination of genetic, lifestyle, and environmental
factors and comprise common noncommunicable diseases, including allergies …
factors and comprise common noncommunicable diseases, including allergies …
The genetic architecture and evolution of the human skeletal form
The human skeletal form underlies bipedalism, but the genetic basis of skeletal proportions
(SPs) is not well characterized. We applied deep-learning models to 31,221 x-rays from the …
(SPs) is not well characterized. We applied deep-learning models to 31,221 x-rays from the …
[HTML][HTML] Height-Related Polygenic Variants Are Associated with Metabolic Syndrome Risk and Interact with Energy Intake and a Rice-Main Diet to Influence Height in …
S Park - Nutrients, 2023 - mdpi.com
Adult height is inversely related to metabolic syndrome (MetS) risk, but its genetic impacts
have not been revealed. The present study aimed to examine the hypothesis that adult …
have not been revealed. The present study aimed to examine the hypothesis that adult …
[PDF][PDF] Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts
Polygenic risk scores (PRSs) have been widely explored in precision medicine. However,
few studies have thoroughly investigated their best practices in global populations across …
few studies have thoroughly investigated their best practices in global populations across …
[PDF][PDF] Genotyping and population characteristics of the China Kadoorie Biobank
RG Walters, IY Millwood, K Lin, DS Valle, P McDonnell… - Cell Genomics, 2023 - cell.com
Summary The China Kadoorie Biobank (CKB) is a population-based prospective cohort of>
512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across …
512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across …
Single-cell genomics meets human genetics
In this Review, the authors describe the emerging field of single-cell genetics, which lies at
the intersection of single-cell genomics and human genetics. They review the first single-cell …
the intersection of single-cell genomics and human genetics. They review the first single-cell …