A developmental constraint model of cancer cell states and tumor heterogeneity
AS Patel, I Yanai - Cell, 2024 - cell.com
Cancer is a disease that stems from a fundamental liability inherent to multicellular life forms
in which an individual cell is capable of reneging on the interests of the collective organism …
in which an individual cell is capable of reneging on the interests of the collective organism …
[HTML][HTML] Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells
The developmental origin of blood-forming hematopoietic stem cells (HSCs) is a
longstanding question. Here, our non-invasive genetic lineage tracing in mouse embryos …
longstanding question. Here, our non-invasive genetic lineage tracing in mouse embryos …
scRNA-seq: oh, the joys
V Marx - Nature Methods, 2024 - nature.com
scRNA-seq: oh, the joys | Nature Methods Skip to main content Thank you for visiting nature.com.
You are using a browser version with limited support for CSS. To obtain the best experience …
You are using a browser version with limited support for CSS. To obtain the best experience …
Neurodevelopment and Metabolism in the Maternal-Placental-Fetal Unit
Importance Disturbances in maternal, placental, and fetal metabolism are associated with
developmental outcomes. Associations of maternal, placental, and fetal metabolism with …
developmental outcomes. Associations of maternal, placental, and fetal metabolism with …
Mapping single-cell developmental potential in health and disease with interpretable deep learning
Single-cell RNA sequencing (scRNA-seq) has transformed our understanding of cell fate in
developmental systems. However, identifying the molecular hallmarks of potency-the …
developmental systems. However, identifying the molecular hallmarks of potency-the …
Deep Batch Integration and Denoise of Single‐Cell RNA‐Seq Data
Numerous single‐cell transcriptomic datasets from identical tissues or cell lines are
generated from different laboratories or single‐cell RNA sequencing (scRNA‐seq) protocols …
generated from different laboratories or single‐cell RNA sequencing (scRNA‐seq) protocols …
[HTML][HTML] Multi-condition and multi-modal temporal profile inference during mouse embryonic development
The emergence of single-cell time-series datasets enables modeling of changes in various
types of cellular profiles over time. However, due to the disruptive nature of single-cell …
types of cellular profiles over time. However, due to the disruptive nature of single-cell …
A computational framework for large-scale cell lineage reconstruction
B Kiyota - 2024 - open.library.ubc.ca
The advent of CRISPR-Cas9 genome editing technologies has spurred the development of
large-scale cell lineage tracing systems. These techniques involve integrating synthetic DNA …
large-scale cell lineage tracing systems. These techniques involve integrating synthetic DNA …