Immune imprinting and next-generation coronavirus vaccines

CQ Huang, S Vishwanath, GW Carnell, ACY Chan… - Nature …, 2023 - nature.com
Vaccines based on historical virus isolates provide limited protection from continuously
evolving RNA viruses, such as influenza viruses or coronaviruses, which occasionally spill …

Silent battles: immune responses in asymptomatic SARS-CoV-2 infection

N Le Bert, T Samandari - Cellular & Molecular Immunology, 2024 - nature.com
SARS-CoV-2 infections manifest with a broad spectrum of presentations, ranging from
asymptomatic infections to severe pneumonia and fatal outcomes. This review centers on …

Original SARS-CoV-2 monovalent and Omicron BA. 4/BA. 5 bivalent COVID-19 mRNA vaccines: phase 2/3 trial interim results

S Chalkias, JL Whatley, F Eder, B Essink, S Khetan… - Nature Medicine, 2023 - nature.com
This ongoing, open-label, phase 2/3 trial compared the safety and immunogenicity of the
Omicron BA. 4/BA. 5-containing bivalent mRNA-1273.222 vaccine with the ancestral Wuhan …

Functional SARS-CoV-2 cross-reactive CD4+ T cells established in early childhood decline with age

M Humbert, A Olofsson, D Wullimann… - Proceedings of the …, 2023 - National Acad Sciences
Pre-existing SARS-CoV-2-reactive T cells have been identified in SARS-CoV-2-unexposed
individuals, potentially modulating COVID-19 and vaccination outcomes. Here, we provide …

Divergent adaptive immune responses define two types of long COVID

J Kervevan, I Staropoli, D Slama… - Frontiers in …, 2023 - frontiersin.org
Background The role of adaptive immune responses in long COVID remains poorly
understood, with contrasting hypotheses suggesting either an insufficient antiviral response …

Persistent humoral immune response in youth throughout the COVID-19 pandemic: Prospective school-based cohort study

A Raineri, T Radtke, S Rueegg, SR Haile… - Nature …, 2023 - nature.com
Understanding the development of humoral immune responses of children and adolescents
to SARS-CoV-2 is essential for designing effective public health measures. Here we …

Vaccine development against tuberculosis before and after Covid-19

SHE Kaufmann - Frontiers in Immunology, 2023 - frontiersin.org
Coronavirus disease (Covid-19) has not only shaped awareness of the impact of infectious
diseases on global health. It has also provided instructive lessons for better prevention …

The role of SARS-CoV-2 N protein in diagnosis and vaccination in the context of emerging variants: Present status and prospects

W Song, Z Fang, F Ma, J Li, Z Huang, Y Zhang… - Frontiers in …, 2023 - frontiersin.org
Despite many countries rapidly revising their strategies to prevent contagions, the number of
people infected with Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease

E Barnes, CS Goodyear, M Willicombe, C Gaskell… - Nature medicine, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune responses and
infection outcomes were evaluated in 2,686 patients with varying immune-suppressive …

Net-Shaped DNA Nanostructure-Based Lateral Flow Assays for Rapid and Sensitive SARS-CoV-2 Detection

S Umrao, M Zheng, X Jin, S Yao, X Wang - Analytical Chemistry, 2024 - ACS Publications
Lateral flow assay (LFA)-based rapid antigen tests are experiencing extensive global uptake
as an expeditious and highly effective modality for the screening of viral infections during the …