Cancer has been a leading cause of death for decades. This dismal statistic has increased
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …

Hematopoietic stem cells (HSCs) possess two important properties such as self-renewal and
differentiation. These properties of HSCs are maintained through hematopoiesis. This …

Chromatin-binding proteins are critical regulators of cell state in haematopoiesis,. Acute
leukaemias driven by rearrangement of the mixed lineage leukaemia 1 gene (KMT2A r) or …

A sleepless night may feel awful in its aftermath, but sleep's revitalizing powers are
substantial, perpetuating the idea that convalescent sleep is a consequence-free …

Abstract Development can be altered to match phenotypes with the environment, and the
genetic mechanisms that direct such alternative phenotypes are beginning to be elucidated …

Basophils are the rarest granulocytes and are recognized as critical cells for type 2 immune
responses. However, their differentiation pathway remains to be fully elucidated. Here, we …

Clinical evidence highlights a relationship between the blood and the bone, but the
underlying mechanism linking these two tissues is not fully elucidated. Here, we used β …

Hematopoietic stem and progenitor cells (HSPCs) are cells mainly present in the bone
marrow and capable of forming mature blood cells. However, the epigenetic mechanisms …

Clonal hematopoiesis of indeterminate potential (CHIP), a common aging-related process
that predisposes individuals to various inflammatory responses, has been reported to be …

In normal somatic tissue differentiation, changes in chromatin accessibility govern priming
and commitment of precursors towards cellular fates. In turn, somatic mutations can disrupt …