The evolutionary history of cancer begins with the acquisition of somatic mutations that lead
to clonal outgrowths. As clones grow, they further undergo genetic diversification that can …

Hematopoietic stem cells (HSCs) are rare cells on top of the differentiation hierarchy of
hematopoiesis. HSCs are unique in their combined capacity to differentiate into all mature …

Hematopoiesis, the process of generating all blood and immune cells from hematopoietic
stem cells (HSCs), is a tightly regulated process orchestrated by cell-intrinsic and cell …

Acute myeloid leukemia (AML) is a complex hematological malignancy marked by
proliferation of immature myeloid cells with a dismal 5-year survival. A major challenge is the …

Polycomb group (PcG) proteins are transcriptional repressors that control development and
cell fate. Polycomb Repressive Complex 2 (PRC2) misfunction has been recurrently …

Although our understanding of the genetic basis of T-cell acute lymphoblastic leukemia (T-
ALL) has improved with next-generation sequencing efforts, features underlying poor …

Introdução: O alo-HSCT é considerado uma abordagem terapéutica altamente curativa para
doentes com leucemias agudas. No entanto, sendo a recidiva e consequente progressão …

A. Abstract Daily hematopoietic cells are produced in the bone marrow (BM) in a process
termed as hematopoiesis. At the apex of hematopoiesis, the hematopoietic stem cells (HSC) …

In cancer, the branched-chain amino acid (BCAA) metabolism is frequently activated
through the increased uptake (second only to glutamine) of valine, leucine, and isoleucine …

Hematopoiesis is strictly regulated to sustain blood production throughout adult life. De novo
DNA methyltransferase 3-alpha (DNMT3A) is one of the major epigenetic regulators found to …