严重烧伤, 创伤及外科大手术应激打击极易诱发脓毒症(sepsis) 等感染并发症,
进一步发展可导致脓毒性休克, 多器官功能障碍综合征(MODS), 是临床烧伤 …

Impaired immune function and associated immunosuppression are hallmarks of septic
syndromes. As part of an overall deactivation of the immune system, profound depletion of …

Carbon-ion radiotherapy (CIRT) is an advanced radiotherapy and has achieved good local
control, even in tumors that are resistant to conventional photon beam radiotherapy (PBRT) …

Background Patients with type 1 autoimmune pancreatitis (AIP) have several immunologic
and histologic abnormalities. It is known that depletion of B cells by rituximab is effective for …

Dendritic cells (DCs) are composed of multiple subsets that play a dual role in inducing
immunity and tolerance. However, it is unclear how CD205+ conventional DCs (cDCs) …

Cutaneous leishmaniasis associated with Leishmania amazonensis infection is
characterized by uncontrolled parasite replication and profound immunosuppression; …

Background & Aims: Crohn's disease is a chronic debilitating disease characterized by
severe T helper cell (Th) 1-driven inflammation of the colon partially caused by a loss of …

There is evidence that Foxp3+ regulatory T (TR) cells contribute to intestinal homeostasis
and that deficiencies in this population can lead to chronic intestinal inflammation. Here, we …

Recent work suggests that dendritic cells (DCs) in mucosal tissues are “educated” by
intestinal epithelial cells (IECs) to suppress inflammation and promote immunological …

Immune responses against pathogens require fine regulation to avoid excessive
inflammation, which could be harmful to the host. Moreover, the immune system must be …