Malaria vaccines: progress to date

DI Stanisic, MF Good - BioDrugs, 2023 - Springer
Malaria is a mosquito-borne disease caused by protozoan parasites of the genus
Plasmodium. Despite significant declines in malaria-attributable morbidity and mortality over …

Malaria vaccines: from the past towards the mRNA vaccine era

ME Tsoumani, C Voyiatzaki, A Efstathiou - Vaccines, 2023 - mdpi.com
Plasmodium spp. is the etiological agent of malaria, a life-threatening parasitic disease
transmitted by infected mosquitoes. Malaria remains a major global health challenge …

Five decades of clinical assessment of whole-sporozoite malaria vaccines

H Nunes-Cabaço, D Moita, M Prudêncio - Frontiers in Immunology, 2022 - frontiersin.org
In 1967, pioneering work by Ruth Nussenzweig demonstrated for the first time that irradiated
sporozoites of the rodent malaria parasite Plasmodium berghei protected mice against a …

Sporozoite immunization: innovative translational science to support the fight against malaria

TL Richie, LWP Church, T Murshedkar… - Expert review of …, 2023 - Taylor & Francis
Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened
247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in …

Host-parasite interactions during Plasmodium infection: Implications for immunotherapies

P Chandley, R Ranjan, S Kumar, S Rohatgi - Frontiers in Immunology, 2023 - frontiersin.org
Malaria is a global infectious disease that remains a leading cause of morbidity and mortality
in the developing world. Multiple environmental and host and parasite factors govern the …

A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletion

D Goswami, H Patel, W Betz, J Armstrong… - EMBO Molecular …, 2024 - embopress.org
Vaccination with infectious Plasmodium falciparum (Pf) sporozoites (SPZ) administered with
antimalarial drugs (PfSPZ-CVac), confers superior sterilizing protection against infection …

Vaccines and monoclonal antibodies: new tools for malaria control

K Miura, Y Flores-Garcia, CA Long… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Malaria remains one of the biggest health problems in the world. While significant reductions
in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend …

Efficacy of a Pseudomonas aeruginosa serogroup O9 vaccine

DA Moustafa, A DiGiandomenico… - Infection and …, 2023 - Am Soc Microbiol
There are currently no approved vaccines against the opportunistic pathogen Pseudomonas
aeruginosa. Among vaccine targets, the lipopolysaccharide (LPS) O antigen of P …

Advancements and challenges in developing malaria vaccines: Targeting multiple stages of the parasite life cycle

Rajneesh, R Tiwari, VK Singh, A Kumar… - ACS Infectious …, 2023 - ACS Publications
Malaria, caused by Plasmodium species, remains a major global health concern, causing
millions of deaths annually. While the introduction of the RTS, S vaccine has shown promise …

Development of an automated biomaterial platform to study mosquito feeding behavior

KD Janson, BH Carter, SB Jameson… - … in Bioengineering and …, 2023 - frontiersin.org
Mosquitoes carry a number of deadly pathogens that are transmitted while feeding on blood
through the skin, and studying mosquito feeding behavior could elucidate countermeasures …