Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease. Recent
findings have shown a marked metabolic reprogramming associated with changes in …

The management of cardiovascular risk through lifestyle modification and pharmacotherapy
is paramount to the prevention of cardiovascular disease. Epidemiological studies have …

Objective—Defective autophagy in macrophages leads to pathological processes that
contribute to atherosclerosis, including impaired cholesterol metabolism and defective …

Carnitine Palmitoyl-Transferase1A (CPT1A) is the rate-limiting enzyme in the fatty acid β-
oxidation, and its deficiency or abnormal regulation can result in diseases like metabolic …

Alterations in the metabolic control of lipid and glucose homeostasis predispose an
individual to develop cardiometabolic diseases, such as type 2-diabetes mellitus and …

Diabetes is the most common metabolic disorder and is recognized as one of the most
important health threats of our time. MicroRNAs (miRNAs) are a novel group of non-coding …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …

Objective Exosomes from obese adipose contain dysregulated microRNAs linked to insulin
signaling, as compared with lean controls, providing a direct connection between adiposity …

Diabetic patients treated with metformin have a reduced incidence of cancer and cancer-
related mortality. Here we show that metformin affects engraftment and growth of breast …

Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and
metastasis. A developmental programme known as epithelial-to-mesenchymal transition …