Atherosclerosis remains the leading cause of a broad spectrum of deadliest cardiovascular
diseases. MicroRNA‐33 is a new therapeutic target for atherosclerosis due to its diverse …

Sirtuins, initially described as histone deacetylases and gene silencers in yeast, are now
known to have much more functions and to be much more abundant in living organisms …

Cellular and plasma lipid levels are tightly controlled by complex gene regulatory
mechanisms. Elevated plasma lipid content, or hyperlipidemia, is a significant risk factor for …

Nonalcoholic fatty liver disease (NAFLD) defines a wide pathological spectrum ranging from
simple steatosis to nonalcoholic steatohepatitis (NASH) which may predispose to liver …

The reduced protein expression of SIRT6 tumor suppressor is involved in tumorigenesis.
The molecular mechanisms underlying SIRT6 protein downregulation in human cancers …

Background—Epigenetic mechanisms might be involved in the regulation of interindividual
lipid level variability and thus may contribute to the cardiovascular risk profile. The aim of this …

Cholesterol homeostasis is among the most intensely regulated processes in biology. Since
its isolation from gallstones at the time of the French Revolution, cholesterol has been …

Latent tuberculosis infection (LTBI) has become a major source of active tuberculosis (ATB).
Although the tuberculin skin test and interferon-gamma release assay can be used to …

The human genome encodes thousands of long noncoding RNAs (lncRNAs), the majority of
which are poorly conserved and uncharacterized. Here we identify a primate-specific …

Rationale: Foam cell formation because of excessive accumulation of cholesterol by
macrophages is a pathological hallmark of atherosclerosis, the major cause of morbidity and …