Background Cancer cells possess a common metabolic phenotype, rewiring their metabolic
pathways from mitochondrial oxidative phosphorylation to aerobic glycolysis and anabolic …

The insulin signaling pathway is composed of a large number of molecules that positively or
negatively modulate insulin specific signal transduction following its binding to the cognate …

Recent discoveries have revealed that microRNAs (miRNAs) play a key role in the
regulation of gene expression. In this review, we summarize the rapidly evolving knowledge …

Non-alcoholic fatty liver disease (NAFLD), a common hepatic disorder ranging from simple
steatosis through steatohepatitis to fibrosis and cirrhosis, is an emerging health concern …

The accumulation of lipids within drusen, the epidemiologic link of a high fat diet, and the
identification of polymorphisms in genes involved in lipid metabolism that are associated …

MicroRNAs (miRNAs) are endogenous small RNAs that posttranscriptionally regulate gene
expression and that have been shown to have important roles in numerous disease …

As an important regulator of macrophage cholesterol efflux and HDL biogenesis, miR-33 is a
promising target for treatment of atherosclerosis, and numerous studies demonstrate that …

Bile secretion is essential for whole body sterol homeostasis. Loss‐of‐function mutations in
specific canalicular transporters in the hepatocyte disrupt bile flow and result in cholestasis …

Elevated plasma triglyceride (TG) concentrations are associated with an increased risk of
atherosclerotic cardiovascular disease (CVD), hepatic steatosis and pancreatitis. Existing …

Obesity is a serious health problem worldwide associated with an increased risk of life-
threatening diseases such as type 2 diabetes, atherosclerosis, and certain types of cancer …