Metabolic diseases are characterized by the failure of regulatory genes or proteins to
effectively orchestrate specific pathways involved in the control of many biological …

Rationale: Therapeutically targeting macrophage reverse cholesterol transport is a
promising approach to treat atherosclerosis. Macrophage energy metabolism can …

SIRT 6 is a pivotal regulator of lipid metabolism. It is also closely connected to
cardiovascular diseases, which are the main cause of death in diabetic patients. We …

The NAD+-dependent protein deacetylase SIRT6 regulates genome stability, cancer, and
lifespan. Mice overexpressing SIRT6 (MOSES) have lower low-density lipoprotein …

Physical exercise induces several metabolic adaptations to meet increased energy
requirements. Promoter DNA methylation, histone post-translational modifications, or …

Dysregulated metabolism is a common feature of cancer cells and is considered a hallmark
of cancer. Altered tumor-metabolism confers an adaptive advantage to cancer cells to fulfill …

While therapeutic modulation of miRNAs provides a promising approach for numerous
diseases, the promiscuous nature of miRNAs raises concern over detrimental off-target …

Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease and
ranges from steatosis to steatohepatitis and to liver fibrosis. Lipotoxicity in hepatocytes …

Global awareness is rising regarding the health implications of global climate change and
environmental pollutants, which are hazardous to both human and animal welfare. Teleost …

Cholesterol metabolism is tightly regulated at the cellular level and is essential for cellular
growth. microRNAs (miRNAs), a class of noncoding RNAs, have emerged as critical …