Simple Summary A promising approach to combat aggressive prostate cancer involves
androgen receptor degraders, which break down the crucial protein driving cancer …

PROteolysis TArgeting Chimera (PROTAC) is an emerging technology in chemical biology
and drug discovery. This technique facilitates the complete removal of the target proteins …

Proteolysis-targeting chimeras (PROTACs) describe compounds that bind to and induce
degradation of a target by simultaneously binding to a ubiquitin ligase. More generally …

Dysregulated transcription factor activity is a defining feature of various cancer types. As
such, targeting oncogenic transcriptional dependency has long been pursued as a potential …

The spread of the influenza virus has caused devastating pandemics and huge economic
losses worldwide. Antiviral drugs with diverse action modes are urgently required to …

Targeted protein degradation (TPD), including the use of proteolysis-targeting chimeras
(PROTACs) and molecular glue degraders (MGDs) to degrade proteins, is an emerging …

Targeted protein degradation (TPD) is a rapidly expanding field, with various PROTACs
(proteolysis-targeting chimeras) in clinical trials and molecular glues such as …

Targeted protein degradation or TPD, is rapidly emerging as a treatment that utilizes small
molecules to degrade proteins that cause diseases. TPD allows for the selective removal of …

Kelch-like proteins (KLHLs) are a large family of BTB-containing proteins. KLHLs function as
the substrate adaptor of Cullin 3-RING ligases (CRL3) to recognize substrates. KLHLs play …

Undruggable targets typically refer to a class of therapeutic targets that are difficult to target
through conventional methods or have not yet been targeted, but are of great clinical …