The nitro group is considered to be a versatile and unique functional group in medicinal
chemistry. Despite a long history of use in therapeutics, the nitro group has toxicity issues …

Abstract Chagas disease and Human African trypanosomiasis (HAT) are caused by
Trypanosoma cruzi, T. brucei rhodesiense or T. b. gambiense parasites, respectively; while …

Due to the lack of specific vaccines, management of the trypanosomatid-caused neglected
tropical diseases (sleeping sickness, Chagas disease and leishmaniasis) relies exclusively …

One of the main problems of Chagas disease (CD), the parasitic infection caused by
Trypanosoma cruzi, is the lack of a completely satisfactory treatment, which is currently …

Twenty different infectious disorders induced by bacteria, viruses, and parasites are
categorized as neglected tropical diseases (NTDs) by WHO. The severity of chagas disease …

A series of new phthalazine derivatives (1–4) containing imidazole rings and functionalized
with nitro groups in the benzene ring of the phthalazine moiety were prepared and identified …

Background: The American trypanosomiasis, Chagas disease, is a parasitic infection
typically spread by triatomine vectors affecting millions of people all over Latin America …

Two series of new 5-nitroindazole derivatives, 1-substituted 2-benzylindazolin-3-ones (6–
29, series A) and 3-alkoxy-2-benzyl-2H-indazoles (30–37, series B), containing differently …

The synthesis of unsymmetrical ferrocenyl and cyrhetrenyl azines [(η 5-C 5 H 4)-CR= NN=
CH-2-C 4 H 2 X-5-NO 2] M (M= Re (CO) 3, Fe (η 5-C 5 H 5); R= H, CH 3, X= O, S) has led to …

Indazole is a vital nitrogen-containing heterocyclic unit in organic and medicinal chemistry
research and a helpful precursor molecule for the production of various types of …