Research on the genetics of complex traits overwhelmingly focuses on the additive effects of
genes. Yet, animal studies have shown that non-additive effects, in particular homozygosity …

It is long known that inbreeding increases the detrimental effects of recessive sequence
variants in “Runs of Homozygosity”(ROHs). However, although the phenotypic association of …

Runs of homozygosity (ROH) have been widely used to study population history and trait
architecture in humans and livestock species, but their application in self-incompatible …

The founder population of Newfoundland and Labrador (NL) is a unique genetic resource, in
part due to its geographic and cultural isolation, where historical records describe a …

Although still prevalent in many human societies, the practice of cousin marriage has
precipitously declined in populations undergoing rapid demographic and socioeconomic …

Abstract Background Multilocus pathogenic variants (MPVs) are genetic changes that affect
multiple gene loci or regions of the genome, collectively leading to multiple molecular …

Familial risk of lung cancer has been widely studied but whether this association holds in
non-smoking females is largely unknown. We sought to determine the relationship between …

By providing additional opportunities for coalescence within families, the presence of
consanguineous unions in a population reduces coalescence times relative to non …

Runs of homozygosity (ROH) segments, contiguous homozygous regions in a genome were
traditionally linked to families and inbred populations. However, a growing literature …

Autozygosity is associated with rare Mendelian disorders and clinically relevant quantitative
traits. We investigated associations between the fraction of the genome in runs of …