Most head and neck cancers are derived from the mucosal epithelium in the oral cavity,
pharynx and larynx and are known collectively as head and neck squamous cell carcinoma …

The last decade has seen significant advances in our understanding of lung cancer biology
and management. Identification of key driver events in lung carcinogenesis has contributed …

Abstract The Cancer Genome Atlas profiled 279 head and neck squamous cell carcinomas
(HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we …

Recent genomic analyses of pathologically defined tumor types identify" within-a-tissue"
disease subtypes. However, the extent to which genomic signatures are shared across …

Here, we present Perturb-ATAC, a method that combines multiplexed CRISPR interference
or knockout with genome-wide chromatin accessibility profiling in single cells based on the …

The survival of patients with oral squamous cell carcinoma (OSCC) has not changed
significantly in several decades, leading clinicians and investigators to search for promising …

Recruitment of myeloid-derived suppressor cells (MDSCs) into tumors induces local
immunosuppression in carcinomas. Here, we assessed whether SX-682, an orally …

Head and neck squamous cell carcinoma (HNSCC) is a frequently fatal heterogeneous
disease. Beyond the role of human papilloma virus (HPV), no validated molecular …

The cellular response to survive or to undergo death is fundamental to the benefit of the
organism, and errors in this process can lead to autoimmunity and cancer. The transcription …

Cancer stem cells (CSCs) may serve as the cellular seeds of tumor recurrence and
metastasis, and they can be generated via epithelial-mesenchymal transitions (EMTs) …