Cancer stem cells in hepatocellular carcinoma—from origin to clinical implications

TKW Lee, XY Guan, S Ma - Nature reviews Gastroenterology & …, 2022 - nature.com
Hepatocellular carcinoma (HCC) is an aggressive disease with a poor clinical outcome. The
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …

MicroRNAs as regulators, biomarkers and therapeutic targets in liver diseases

X Wang, Y He, B Mackowiak, B Gao - Gut, 2021 - gut.bmj.com
MicroRNAs (miRNAs) are small, non-coding RNAs that post-transcriptionally regulate gene
expression by binding to specific mRNA targets and promoting their degradation and/or …

[HTML][HTML] Role of miRNA-regulated cancer stem cells in the pathogenesis of human malignancies

AQ Khan, EI Ahmed, NR Elareer, K Junejo, M Steinhoff… - Cells, 2019 - mdpi.com
Recent biomedical discoveries have revolutionized the concept and understanding of
carcinogenesis, a complex and multistep phenomenon which involves accretion of genetic …

miRNAs inspirations in hepatocellular carcinoma: detrimental and favorable aspects of key performers

HA El-Mahdy, AAM Sallam, A Ismail… - … -Research and practice, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related deaths
worldwide. HCC initiation, progression, and therapy failure are all influenced by various …

[HTML][HTML] Solamargine induces hepatocellular carcinoma cell apoptosis and autophagy via inhibiting LIF/miR-192-5p/CYR61/Akt signaling pathways and eliciting …

S Yin, W Jin, Y Qiu, L Fu, T Wang, H Yu - Journal of Hematology & …, 2022 - Springer
Hepatocellular carcinoma (HCC) is well-known to be a highly prevalent malignant tumor, but
the treatment of this pathological state has been still challenging. Solamargine (SM), a …

[HTML][HTML] HBX-induced miR-5188 impairs FOXO1 to stimulate β-catenin nuclear translocation and promotes tumor stemness in hepatocellular carcinoma

X Lin, S Zuo, R Luo, Y Li, G Yu, Y Zou, Y Zhou, Z Liu… - Theranostics, 2019 - ncbi.nlm.nih.gov
Cancer stem cells (CSCs) are the key factor in determining cancer recurrence, metastasis,
chemoresistance and patient prognosis in hepatocellular carcinoma (HCC). The role of miR …

[HTML][HTML] Emerging role of MiR-192-5p in human diseases

F Ren, Y Yao, X Cai, G Fang - Frontiers in Pharmacology, 2021 - frontiersin.org
MicroRNAs (miRNAs) are a type of small non-coding RNAs that play an essential role in
numerous biological processes by regulating the post-transcriptional expression of target …

MiR‐125b loss activated HIF1α/pAKT loop, leading to transarterial chemoembolization resistance in hepatocellular carcinoma

X Wei, L Zhao, R Ren, F Ji, S Xue, J Zhang, Z Liu… - …, 2021 - Wiley Online Library
Background and Aims Transarterial chemoembolization (TACE) is a standard locoregional
therapy for patients with hepatocellular carcinoma (HCC) patients with a variable overall …

[HTML][HTML] Dysregulated microRNAs in hepatitis B virus-related hepatocellular carcinoma: potential as biomarkers and therapeutic targets

J Xu, P An, CA Winkler, Y Yu - Frontiers in oncology, 2020 - frontiersin.org
MicroRNAs (miRNAs) are non-coding small RNAs that can function as gene regulators and
are involved in tumorigenesis. We review the commonly dysregulated miRNAs in liver tumor …

[HTML][HTML] Diagnostic significance of hsa-miR-21-5p, hsa-miR-192-5p, hsa-miR-155-5p, hsa-miR-199a-5p panel and ratios in hepatocellular carcinoma on top of liver …

MA Eldosoky, R Hammad, AA Elmadbouly… - International journal of …, 2023 - mdpi.com
Early hepatocellular carcinoma (HCC) diagnosis is challenging. Moreover, for patients with
alpha-fetoprotein (AFP)-negative HCC, this challenge is augmented. MicroRNAs (miRs) …