[HTML][HTML] Snake venom peptides: Tools of biodiscovery
Nature endowed snakes with a lethal secretion known as venom, which has been fine-tuned
over millions of years of evolution. Snakes utilize venom to subdue their prey and to survive …
over millions of years of evolution. Snakes utilize venom to subdue their prey and to survive …
[HTML][HTML] From Snake venoms to therapeutics: a focus on natriuretic peptides
Snake venom is a cocktail of multifunctional biomolecules that has evolved with the purpose
of capturing prey and for defense. These biomolecules are classified into different classes …
of capturing prey and for defense. These biomolecules are classified into different classes …
Omics technologies for profiling toxin diversity and evolution in snake venom: impacts on the discovery of therapeutic and diagnostic agents
Snake venoms are primarily composed of proteins and peptides, and these toxins have
developed high selectivity to their biological targets. This makes venoms interesting for …
developed high selectivity to their biological targets. This makes venoms interesting for …
Toxins are an excellent source of therapeutic agents against cardiovascular diseases
Venomous and hematophagous animals use their venom or saliva for survival, to obtain
food, and for self-defense. Venom and saliva from these animals are cocktails of bioactive …
food, and for self-defense. Venom and saliva from these animals are cocktails of bioactive …
Venom natriuretic peptides guide the design of heart failure therapeutics
Heart failure (HF) affects over 26 million people world-wide. It is a syndrome triggered by
loss of normal cardiac function due to many acute (eg myocardial infarction) and/or chronic …
loss of normal cardiac function due to many acute (eg myocardial infarction) and/or chronic …
[HTML][HTML] Unveiling the potential role of natriuretic peptide receptor a isoforms in fine-tuning the cGMP production and tissue-specific function
Atrial natriuretic peptide (ANP) is a peptide hormone that regulates blood pressure and
volume. ANP interacts with natriuretic peptide receptor-A (NPR-A) to lower the blood …
volume. ANP interacts with natriuretic peptide receptor-A (NPR-A) to lower the blood …
Natriuretic peptide analogues with distinct vasodilatory or renal activity: integrated effects in health and experimental heart failure
MT Rademaker, NJA Scott, CY Koh… - Cardiovascular …, 2021 - academic.oup.com
Aims Management of acute decompensated heart failure (ADHF) requires disparate
treatments depending on the state of systemic/peripheral perfusion and the …
treatments depending on the state of systemic/peripheral perfusion and the …
[HTML][HTML] Toxinology provides multidirectional and multidimensional opportunities: a personal perspective
RM Kini - Toxicon: X, 2020 - Elsevier
In nature, toxins have evolved as weapons to capture and subdue the prey or to counter
predators or competitors. When they are inadvertently injected into humans, they cause …
predators or competitors. When they are inadvertently injected into humans, they cause …
[HTML][HTML] Taipan Natriuretic Peptides Are Potent and Selective Agonists for the Natriuretic Peptide Receptor A
Cardiovascular ailments are a major cause of mortality where over 1.3 billion people suffer
from hypertension leading to heart-disease related deaths. Snake venoms possess a broad …
from hypertension leading to heart-disease related deaths. Snake venoms possess a broad …
Exogenous factors from venomous and hematophagous animals in drugs and diagnostic developments for cardiovascular and neurovascular diseases
Venomous animals such as snakes, spiders, scorpions, bees, cone snails, and sea
anemones and hematophagous animals like ticks, leeches, mosquitoes, vampire bats, and …
anemones and hematophagous animals like ticks, leeches, mosquitoes, vampire bats, and …