Fluorine-a small magic bullet atom in the drug development: perspective to FDA approved and COVID-19 recommended drugs

G Chandra, DV Singh, GK Mahato, S Patel - Chemical Papers, 2023 - Springer
During the last twenty years, organic fluorination chemistry established itself as an important
tool to get a biologically active compound. This belief can be supported by the fact that every …

Small Molecule Probes for 19F Magnetic Resonance Imaging

A Li, X Luo, D Chen, L Li, H Lin, J Gao - Analytical Chemistry, 2023 - ACS Publications
MRI, which takes advantage of the difference in relaxation times for high concentration of
mobile water (∼ 80 M1h) in various tissues, 11 has demonstrated its outstanding capacity …

Cell-Interactive Gelatin-Based 19F MRI Tracers: An In Vitro Proof-of-Concept Study

K Kolouchova, O Groborz, V Herynek… - Chemistry of …, 2023 - ACS Publications
Cross-linked gelatin-based hydrogels are highly promising cell-interactive, biocompatible,
and biodegradable materials serving tissue engineering. Moreover, gelatins with covalently …

Study of Carbamoyl Fluoride: Synthesis, Properties and Applications

C Bonnefoy, E Chefdeville, C Tourvieille… - … A European Journal, 2022 - Wiley Online Library
Carbamoyl fluoride is a fluorinated group that, to this date, remains underexplored, probably
due to the lack of data concerning its properties. In this paper, a study of carbamoyl fluoride …

Ultra-hybrid sensor based on magnetic and fluorescent biomaterial for the sensitive/selective detection of toxic Ag+ and Hg2+ ions in real samples

A Bilgic, A Cimen, M Bayrak, AN Kursunlu - Materials Today Sustainability, 2024 - Elsevier
The development of high-performance, eco-friendly and magnetic sensors prepared from
natural products have recently attracted a lot of attention for the selective detection of metal …

Tuning the pH of Activation of Fluorinated Hydrazone-Based Switches─A Pathway to Versatile 19F Magnetic Resonance Imaging Contrast Agents

D Janasik, P Imielska, T Krawczyk - ACS sensors, 2023 - ACS Publications
Molecular switches have become an area of great interest in recent years. They are
explored as high-density data storage and organic diodes in molecular electronics as well …

Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives

J Zhao, X Li, T Ma, B Chang, B Zhang… - Medicinal Research …, 2024 - Wiley Online Library
The burgeoning prodrug strategy offers a promising avenue toward improving the efficacy
and specificity of cytotoxic drugs. Elevated intracellular levels of glutathione (GSH) have …

Recent Research Progress of 19F Magnetic Resonance Imaging Probes: Principle, Design, and Their Application

Y Mo, C Huang, C Liu, Z Duan, J Liu… - Macromolecular Rapid …, 2023 - Wiley Online Library
Visualization of biomolecules, cells, and tissues, as well as metabolic processes in vivo is
significant for studying the associated biological activities. Fluorine magnetic resonance …

Ratiometric pH-Responsive 19F Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches

D Janasik, K Jasiński, WP Węglarz, I Nemec… - Analytical …, 2022 - ACS Publications
Hydrazone-based molecular switches serve as efficient ratiometric pH-sensitive agents that
can be tracked with 19F NMR/MRI and 1H NMR. Structural changes induced between pH 3 …

Self-assembling dendrimer nanosystems for specific fluorine magnetic resonance imaging and effective theranostic treatment of tumors

Z Lyu, B Ralahy, TA Perles-Barbacaru… - Proceedings of the …, 2024 - National Acad Sciences
Fluorine magnetic resonance imaging (19F-MRI) is particularly promising for biomedical
applications owing to the absence of fluorine in most biological systems. However, its use …