The shared role of amyloid-β (Aβ) deposition in cerebral amyloid angiopathy (CAA) and
Alzheimer disease (AD) is arguably the clearest instance of crosstalk between …

The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …

The blood–brain barrier (BBB) protects the central nervous system (CNS) from unregulated
exposure to the blood and its contents. The BBB also controls the blood-to-brain and brain …

Accumulation of toxic protein aggregates—amyloid-β (Aβ) plaques and
hyperphosphorylated tau tangles—is the pathological hallmark of Alzheimer disease (AD) …

The vascular basement membrane contributes to the integrity of the blood-brain barrier
(BBB), which is formed by brain capillary endothelial cells (BCECs). The BCECs receive …

Brain capillary endothelial cells form the blood-brain barrier (BBB), which is covered with
basement membranes and is also surrounded by pericytes and astrocyte end-feet in the …

Interstitial fluid (ISF) surrounds the parenchymal cells of the brain and spinal cord while
cerebrospinal fluid (CSF) fills the larger spaces within and around the CNS. Regulation of …

Immune privilege of the central nervous system (CNS) has been ascribed to the presence of
a blood–brain barrier and the lack of lymphatic vessels within the CNS parenchyma …

Cerebrovascular disease (CVD) and Alzheimer's disease (AD) have more in common than
their association with ageing. They share risk factors and overlap neuropathologically. Most …

The belief that the vertebrate brain functions normally without classical lymphatic drainage
vessels has been held for many decades. On the contrary, new findings show that functional …