Role of Kynurenine and Its Derivatives in the Neuroimmune System

M Fujikawa, M Ueda, K Maruyama - International Journal of Molecular …, 2024 - mdpi.com
In recent years, there has been a growing realization of intricate interactions between the
nervous and immune systems, characterized by shared humoral factors and receptors. This …

Current landscape of fecal microbiota transplantation in treating depression

Q Zhang, Y Bi, B Zhang, Q Jiang, CK Mou… - Frontiers in …, 2024 - frontiersin.org
Depression, projected to be the predominant contributor to the global disease burden, is a
complex condition with diverse symptoms including mood disturbances and cognitive …

[HTML][HTML] Targeting kinase ITK treats autoimmune arthritis via orchestrating T cell differentiation and function

Y Chen, R Liang, X Shi, R Shen, L Liu, Y Liu… - Biomedicine & …, 2023 - Elsevier
IL-2 inducible T cell kinase (ITK) is critical in T helper subset differentiation and its inhibition
has been suggested for the treatment of T cell-mediated inflammatory diseases. T follicular …

[HTML][HTML] Hyperactive lateral habenula mediates the comorbidity between rheumatoid arthritis and depression-like behaviors

P Wu, W Li, R Lv, X Cheng, F Lian, W Cai, Y Hu… - Brain, Behavior, and …, 2024 - Elsevier
Rheumatoid arthritis (RA) patients have a high prevalence for depression. On the other
hand, comorbid with depression is associated with worse prognosis for RA. However, little is …

Mediating role of depression in linking rheumatoid arthritis to all-cause and cardiovascular-related mortality: A prospective cohort study

R La, Y Yin, B Xu, J Huang, L Zhou, W Xu… - Journal of Affective …, 2024 - Elsevier
Objective This study aimed to analyze the associations between rheumatoid arthritis (RA)
and all-cause mortality and cardiovascular disease (CVD)-related mortality using data from …

[HTML][HTML] The depression prevalence in Chinese patients with rheumatoid arthritis: a systematic review and Meta-analysis

J Huang, W Chen, P Zhu - Actas Españolas de Psiquiatría, 2023 - ncbi.nlm.nih.gov
Background: The chronic course and recurring acute episodes of rheumatoid arthritis (RA)
can significantly affect the psychological and mental health of patients. This study aimed to …

Resveratrol nanocrystals based dissolving microneedles with highly efficient for rheumatoid arthritis

N Diao, Y Liu, W Wang, M Cao, X Liu, W Yang… - Drug Delivery and …, 2024 - Springer
Rheumatoid arthritis (RA) is a common immune disease characterized mainly by erosive
arthritis with extensive clinical sequelae. Resveratrol (Res) has pharmacological effects in …

[HTML][HTML] Regional Changes in Brain Biomolecular Markers in a Collagen-Induced Arthritis Rat Model

AME Millen, TT Maluleke, L Pienaar, FN Sallie… - Biology, 2024 - mdpi.com
Simple Summary Auto-immune disorders, such as rheumatoid arthritis, are characterized by
high levels of pro-inflammatory cytokines. Continued exposure to high levels of systemic …

[PDF][PDF] Association between the adherence to Mediterranean diet and depression in rheumatoid arthritis patients: a cross-sectional study from the NHANES database

L Ma, J Yuan, X Yang, M Yan, Y Li, M Niu - Journal of Health, Population …, 2024 - Springer
Background Rheumatoid arthritis (RA) is a systemic autoimmune disease, and depression is
a most frequent comorbid condition associated with RA. Studies have shown that …

Anhedonic behaviour in a TLR7-driven neuroinflammation mouse model is associated with impaired thalamostriatal signalling and immune cell ingress into the brain

D Sharma, L Andrianova, R McGonigal… - bioRxiv, 2024 - biorxiv.org
Depression is a heterogenous condition driven by multiple aetiologies, which make its
pathophysiology challenging to map. Stratifying depression by underlying biological causes …