The cell biology of synapse formation

TC Südhof - Journal of Cell Biology, 2021 - rupress.org
In a neural circuit, synapses transfer information rapidly between neurons and transform this
information during transfer. The diverse computational properties of synapses are shaped by …

[HTML][HTML] Autism spectrum disorder: neurodevelopmental risk factors, biological mechanism, and precision therapy

L Wang, B Wang, C Wu, J Wang, M Sun - International journal of …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a heterogeneous, behaviorally defined
neurodevelopmental disorder. Over the past two decades, the prevalence of autism …

Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis

JH Lee, J Kim, S Noh, H Lee, SY Lee, JY Mun, H Park… - Nature, 2021 - nature.com
In the adult hippocampus, synapses are constantly formed and eliminated,. However, the
exact function of synapse elimination in the adult brain, and how it is regulated, are largely …

[HTML][HTML] Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental …

C Cheroni, N Caporale, G Testa - Molecular autism, 2020 - Springer
The complex pathophysiology of autism spectrum disorder encompasses interactions
between genetic and environmental factors. On the one hand, hundreds of genes …

[HTML][HTML] Genetics of glutamate and its receptors in autism spectrum disorder

S Nisar, AA Bhat, T Masoodi, S Hashem, S Akhtar… - Molecular …, 2022 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental impairment characterized by
deficits in social interaction skills, impaired communication, and repetitive and restricted …

Autism spectrum disorders: etiology and pathology

AK Sauer, J Stanton, S Hans… - Exon Publications, 2021 - exonpublications.com
Autism spectrum disorders (ASD) are a group of neurodevelopmental diseases. The cause
of ASD is unknown, but several genetic and non-genetic risk factors have been …

[HTML][HTML] Role of phosphodiesterases in the pathophysiology of neurodevelopmental disorders

S Delhaye, B Bardoni - Molecular Psychiatry, 2021 - nature.com
Phosphodiesterases (PDEs) are enzymes involved in the homeostasis of both cAMP and
cGMP. They are members of a family of proteins that includes 11 subfamilies with different …

[HTML][HTML] Wnt/β-catenin-dependent transcription in autism spectrum disorders

MO Caracci, ME Avila… - Frontiers in molecular …, 2021 - frontiersin.org
Autism spectrum disorders (ASD) is a heterogeneous group of neurodevelopmental
disorders characterized by synaptic dysfunction and defects in dendritic spine morphology …

The neuroligins and the synaptic pathway in Autism Spectrum Disorder

L Trobiani, M Meringolo, T Diamanti, Y Bourne… - Neuroscience & …, 2020 - Elsevier
The genetics underlying autism spectrum disorder (ASD) is complex and heterogeneous,
and de novo variants are found in genes converging in functional biological processes …

[HTML][HTML] Neurodevelopmental disorders, like cancer, are connected to impaired chromatin remodelers, PI3K/mTOR, and PAK1-regulated MAPK

R Nussinov, BR Yavuz, MK Arici, HC Demirel… - Biophysical …, 2023 - Springer
Neurodevelopmental disorders (NDDs) and cancer share proteins, pathways, and
mutations. Their clinical symptoms are different. However, individuals with NDDs have …