The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many
cellular pathways, including protein synthesis, protein quality control, and lipid synthesis …

Besides protein processing, the endoplasmic reticulum (ER) has several other functions
such as lipid synthesis, the transfer of molecules to other cellular compartments, and the …

Stimulated Raman scattering (SRS) offers the ability to image metabolic dynamics with high
signal-to-noise ratio. However, its spatial resolution is limited by the numerical aperture of …

IRE1α is constitutively active in several cancers and can contribute to cancer progression.
Activated IRE1α cleaves XBP1 mRNA, a key step in production of the transcription factor …

Endoplasmic reticulum (ER) stress and its adaptive mechanism, the unfolded protein
response (UPR), are triggered by the accumulation of unfolded and misfolded proteins …

The past few decades have witnessed significant progress in the discovery of hydrogen
sulfide (H 2 S) as a ubiquitous gaseous signaling molecule in mammalian physiology, akin …

Background Despite the clinical success of androgen receptor (AR)‐targeted therapies,
prostate cancer (PCa) inevitably progresses to castration‐resistant prostate cancer (CRPC) …

The endoplasmic reticulum (ER) is the key organelle for membrane biogenesis. Most lipids
are synthesized in the ER, and most membrane proteins are first inserted into the ER …

Energy metabolism failure in proximal tubule cells (PTCs) is a hallmark of chronic kidney
injury. We combined transcriptomic, metabolomic, and lipidomic approaches in experimental …

Trimethylamine-N-oxide (TMAO) is a molecular metabolite derived from the gut flora, which
has recently emerged as a candidate risk factor for metabolic dysfunction-associated fatty …