[HTML][HTML] Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets

Z Zhang, L Zhao, X Zhou, X Meng, X Zhou - Frontiers in immunology, 2023 - frontiersin.org
Hypertension is regarded as the most prominent risk factor for cardiovascular diseases,
which have become a primary cause of death, and recent research has demonstrated that …

[HTML][HTML] Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology

D Dobrev, J Heijman, R Hiram, N Li… - Nature Reviews …, 2023 - nature.com
Inflammation has been implicated in atrial fibrillation (AF), a very common and clinically
significant cardiac rhythm disturbance, but its precise role remains poorly understood. Work …

[HTML][HTML] Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications

N Potere, MG Del Buono, R Caricchio, PC Cremer… - …, 2022 - thelancet.com
A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …

[HTML][HTML] Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions

J Ma, Y Li, X Yang, K Liu, X Zhang, X Zuo… - Signal transduction and …, 2023 - nature.com
Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

[HTML][HTML] The NLRP3 inflammasome in depression: potential mechanisms and therapies

CY Xia, YX Guo, WW Lian, Y Yan, BZ Ma… - Pharmacological …, 2023 - Elsevier
Increasing evidence suggests that the failure of clinical antidepressants may be related with
neuroinflammation. The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) …

Systemic and ovarian inflammation in women with polycystic ovary syndrome

Y Zhai, Y Pang - Journal of Reproductive Immunology, 2022 - Elsevier
Polycystic ovary syndrome (PCOS) is a common endocrine/reproductive/metabolic disorder.
The etiology of PCOS is complex and has been linked to low-grade chronic inflammation …

[HTML][HTML] Pharmacological cardioprotection against ischemia reperfusion injury—the search for a clinical effective therapy

Q Wang, CJ Zuurbier, R Huhn, C Torregroza… - Cells, 2023 - mdpi.com
Pharmacological conditioning aims to protect the heart from myocardial ischemia-
reperfusion injury (IRI). Despite extensive research in this area, today, a significant gap …

[HTML][HTML] NLRP3 inflammasome activation and SARS-CoV-2-mediated hyperinflammation, cytokine storm and neurological syndromes

D Dutta, J Liu, H Xiong - International journal of physiology …, 2022 - ncbi.nlm.nih.gov
Despite the introduction of vaccines and drugs for SARS-CoV-2, the COVID-19 pandemic
continues to spread throughout the world. In severe COVID-19 patients, elevated levels of …

Mechanisms of NLRP3 inflammasome activation and the development of peptide inhibitors

T Ye, W Tao, X Chen, C Jiang, B Di, L Xu - Cytokine & Growth Factor …, 2023 - Elsevier
The Nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor 3
(NLRP3), a member of the nucleotide-binding oligomerization domain (NOD) like receptors …

Pyroptosis in cardiovascular diseases: pumping gasdermin on the fire

TO Yarovinsky, M Su, C Chen, Y Xiang, WH Tang… - Seminars in …, 2023 - Elsevier
Pyroptosis is a form of programmed cell death associated with activation of inflammasomes
and inflammatory caspases, proteolytic cleavage of gasdermin proteins (forming pores in the …