The genetic basis of human facial variation and craniofacial birth defects remains poorly
understood. Distant-acting transcriptional enhancers control the fine-tuned spatiotemporal …

Single cell transcriptomics has transformed the characterization of brain cell identity by
providing quantitative molecular signatures for large, unbiased samples of brain cell …

Single-cell ATAC sequencing (scATAC-seq) is a powerful and increasingly popular
technique to explore the regulatory landscape of heterogeneous cellular populations …

Single-cell sequencing is a powerful approach that can detect genetic alterations and their
phenotypic consequences in the context of human development, with cellular resolution …

Single-cell data integration can provide a comprehensive molecular view of cells, and many
algorithms have been developed to remove unwanted technical or biological variations and …

In the rapidly evolving landscape of genomics, deep learning has emerged as a useful tool
for tackling complex computational challenges. This review focuses on the transformative …

To gain deeper insights into transcriptomes and epigenomes of organoids, liver organoids
from two states (expandable and more differentiated) were subjected to single-cell RNA-seq …

Skeletal muscle is a complex heterogeneous tissue and characterizing its cellular
heterogeneity and transcriptional and epigenetic signatures are important for understanding …

Plant tissues and organs are composed of functionally discrete cell types that are all defined
by the same genome sequence. Cell-type variation in part arises from differential …

Modern neuroscience approaches including optogenetics, calcium imaging, and other
genetic manipulations have facilitated our ability to dissect specific circuits in rodent models …